Evidence map›Paper›PMID 33895878›Full record

ArticleActa neuropathologica2021

Transmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson's disease.

Achim Thomzig, Katja Wagenführ, Phillip Pinder, Marion Joncic, Walter J Schulz-Schaeffer, Michael Beekes

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Acta neuropathologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

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  14. The gastrointestinal tract and Parkinson's disease.Frontiers in cellular and infection microbiology · 2023
    Review
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  19. The Origins of the Protein Spread in Parkinson's Disease.Movement disorders clinical practice · 2021
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Achim Thomzig *Prion and Prionoid Research Unit, ZBS 6-Proteomics and Spectroscopy, ZBS-Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.
Katja Wagenführ *Prion and Prionoid Research Unit, ZBS 6-Proteomics and Spectroscopy, ZBS-Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.
Phillip PinderPrion and Prionoid Research Unit, ZBS 6-Proteomics and Spectroscopy, ZBS-Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.
Marion JoncicPrion and Prionoid Research Unit, ZBS 6-Proteomics and Spectroscopy, ZBS-Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.
Walter J Schulz-SchaefferInstitute of Neuropathology, Faculty of Medicine, Saarland University, Homburg, Germany.
Michael BeekesPrion and Prionoid Research Unit, ZBS 6-Proteomics and Spectroscopy, ZBS-Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany. BeekesM@rki.de.ORCID http://orcid.org/0000-0002-6454-6657
Robert Koch Institute · DESaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral deposition of abnormally aggregated α-synuclein (αSyn) is a neuropathological hallmark of Parkinson's disease (PD). PD-associated αSyn (αSyn

Indexed as

alpha-SynucleinParkinson DiseaseAnimalsBrainEnteric Nervous SystemHumansLewy BodiesMiceMuscle, SkeletalNeuronsPrionsStomachalpha-SynucleinPrionsSNCA protein, humanAlpha-synucleinMouse bioassayParkinson´s diseaseSeedingStomachTransmission

Identifiers

PMID33895878
PMCPMC8068459
OpenAlexW3158424757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.