Evidence map›Paper›PMID 33895836›Full record

Observational studyJournal of burn care & research : official publication of the American Burn Association2022

Peritraumatic Plasma Omega-3 Fatty Acid Concentration Predicts Chronic Pain Severity Following Thermal Burn Injury.

Matthew C Mauck, Chloe E Barton, Andrew S Tungate, Jeffrey W Shupp, Rachel Karlnoski, David J Smith, Felicia N Williams, Samuel W Jones, Christopher Sefton, Kyle McGrath and 2 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of burn care & research : official publication of the American Burn Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Matthew C MauckInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, USA.
Chloe E BartonInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, USA.ORCID 0000-0002-8895-3695
Andrew S TungateInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, USA.
Jeffrey W ShuppThe Burn Center, MedStar Washington Hospital Center, Department of Surgery, Georgetown University, District of Columbia, USA.
Rachel KarlnoskiDepartment of Surgery, University of South Florida, Tampa, USA.
David J SmithDepartment of Surgery, University of South Florida, Tampa, USA.
Felicia N WilliamsJaycee Burn Center, University of North Carolina at Chapel Hill, USA.
Samuel W JonesJaycee Burn Center, University of North Carolina at Chapel Hill, USA.
Christopher SeftonInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, USA.
Kyle McGrathInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, USA.
Bruce A CairnsJaycee Burn Center, University of North Carolina at Chapel Hill, USA.
Samuel A McLeanInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, USA.
University of North Carolina at Chapel Hill · USUniversity of South Florida · USMedStar Washington Hospital Center · US

Funding

UNC BIRCWH CAREER DEVELOPMENT PROGRAMK12HD001441 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOGGESS, KIM A · 2000 to 2019
$9.3M
NICHD NIH HHSNICHD NIH HHS K12 HD001441NIH HHS K12HD001441
6 · The paper itself

Abstract

Chronic pain is a significant comorbidity of burn injury affecting up to 60% of survivors. Currently, no treatments are available to prevent chronic pain after burn injury. Accumulating evidence suggests that omega-3 fatty acids (O3FAs) improve symptoms across a range of painful conditions. In this study, we evaluated whether low peritraumatic levels of O3FA predict greater pain severity during the year after burn injury. Burn survivors undergoing skin autograft were recruited from three participating burn centers. Plasma O3FA (n = 77) levels were assessed in the early aftermath of burn injury using liquid chromatography/mass spectrometry, and pain severity was assessed via the 0 to 10 numeric rating scale for 1 year following burn injury. Repeated-measures linear regression analyses were used to evaluate the association between peritraumatic O3FA concentrations and pain severity during the year following burn injury. Peritraumatic O3FA concentration and chronic pain severity were inversely related; lower levels of peritraumatic O3FAs predicted worse pain outcomes (β = -0.002, P = .020). Future studies are needed to evaluate biological mechanisms mediating this association and to assess the ability of O3FAs to prevent chronic pain following burn injury.

Indexed as

AdolescentAdultAgedBiomarkersBurnsChronic PainFatty Acids, Omega-3FemaleHumansMaleMiddle AgedPain MeasurementPredictive Value of TestsBiomarkersFatty Acids, Omega-3

Identifiers

PMID33895836
PMCPMC8737082
OpenAlexW3157108687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.