Evidence map›Paper›PMID 33895797›Full record

ArticleEuropean heart journal. Quality of care & clinical outcomes2022

Peak oxygen consumption achieved at the end of cardiac rehabilitation predicts long-term survival in patients with coronary heart disease.

Salvatore Carbone, Youngdeok Kim, Sergey Kachur, Hayley Billingsley, Jonathan Kenyon, Alban De Schutter, Richard V Milani, Carl J Lavie

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PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Quality of care & clinical outcomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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  11. Impact of Body Composition on Peak Oxygen Uptake After Cardiac Rehabilitation.medRxiv : the preprint server for health sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Salvatore CarboneDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, 1020 W Grace Street, Richmond, VA, 23220, USA.ORCID 0000-0002-8163-0527
Youngdeok KimDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, 1020 W Grace Street, Richmond, VA, 23220, USA.ORCID 0000-0002-6134-0100
Sergey KachurJohn Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA.ORCID 0000-0002-8607-7169
Hayley BillingsleyDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, 1020 W Grace Street, Richmond, VA, 23220, USA.ORCID 0000-0002-6239-467X
Jonathan KenyonDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, 1020 W Grace Street, Richmond, VA, 23220, USA.ORCID 0000-0002-2901-9659
Alban De SchutterJohn Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA.
Richard V MilaniJohn Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA.ORCID 0000-0002-6094-8253
Carl J LavieJohn Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA.ORCID 0000-0003-3906-1911
Ochsner Medical Center · USVirginia Commonwealth University · US

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
NCATS NIH HHS UL1 TR002649
6 · The paper itself

Abstract

aimsCardiac rehabilitation (CR) improves survival in patients with coronary heart disease (CHD), which is largely mediated by the improvements in cardiorespiratory fitness (CRF) defined as peak oxygen consumption (VO2). Therefore, measuring CRF is essential to predict long-term outcomes in this population. It is unclear, however, whether peak VO2 achieved at the end of CR (END-peak VO2) predicts survival or whether the changes of CRF achieved during CR provide a greater prognostic value. To determine whether END-peak VO2 independently predicts long-term survival in patients with CHD undergoing CR. We also aimed at identifying cut-offs for END-peak VO2 that could be used in clinical practice. METHODS AND

resultsRetrospective analysis of 853 patients with CHD referred to CR who completed a maximal cardiopulmonary exercise test. Survival analysis was performed to examine the risk of all-cause mortality (average follow-up years: 6.65) based on peak VO2. The Contal and O'Quigley's method was used to determine the optimal cut-off of END-peak VO2 based on the log-rank statistic. END-peak VO2 was inversely associated with mortality risk [hazard ratio (HR) = 0.84; 95% confidence interval (CI) = 0.78-0.90], independent of changes in peak VO2 adjusted for the baseline peak VO2. The estimated cut-off of END-peak VO2 at ≥17.6 mL/kg/min best predicted the survival with high predictive accuracy and patients with END-peak VO2 under the cut-off had a greater risk of mortality (HR = 2.93; 95% CI = 1.81-4.74).

conclusionsIn patient with CHD undergoing CR, END-peak VO2 is an independent predictor for long-term survival. Studies utilizing higher intensity CR programmes, with and without pharmacologic strategies, to increase peak VO2 to a greater degree in those achieving a suboptimal END-peak VO2, are urgently needed.

Indexed as

Cardiac RehabilitationCoronary DiseaseExercise TestHumansOxygen ConsumptionRetrospective StudiesCardiac rehabCardiorespiratory fitnessCoronary heart diseaseExercise training

Identifiers

PMID33895797
PMCPMC9631231
OpenAlexW3158043094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.