Evidence map›Paper›PMID 33895700›Full record

SynthesisJournal of neuroimmunology2021

Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review.

Abu Baker Sheikh, Prabal Kumar Chourasia, Nismat Javed, Mehul Kumar Chourasia, Sajid S Suriya, Shubhra Upadhyay, Fatima Ijaz, Suman Pal, Narges Moghimi, Rahul Shekhar

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neuroimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  12. GBS and COVID-19: Untangling the Knots.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
    Article
  13. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Abu Baker SheikhDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America. Electronic address: absheikh@salud.unm.edu.
Prabal Kumar ChourasiaDepartment of Hospital Medicine, Mary Washington Hospital, Fredericksburg, VA, United States of America.
Nismat JavedDepartment of Internal Medicine, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Mehul Kumar ChourasiaSchool of Medicine, Ninewells Hospital, University of Dundee, UK.
Sajid S SuriyaDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States of America.
Shubhra UpadhyayDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.
Fatima IjazDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.
Suman PalDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.
Narges MoghimiDepartment of Neurology, University of New Mexico, Albuquerque, NM, United States of America.
Rahul ShekharDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, United States of America.
University of New Mexico · USMary Washington Hospital · USNinewells Hospital · GBShifa Tameer-e-Millat University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe systematic review aimed to determine demographic characteristics, clinical features, lab evaluation, management and complications of the studies focusing on Guillain-Barre syndrome (GBS) as a sequele of novel coronavirus (COVID-19) infection.

methodsAfter protocol registration, PubMed, Web of Science and Cumulative Index to Nursing & Allied Health Literature (CINHAL) databases were searched for relevant articles using MeSH key-words and imported into referencing/review softwares. The data, regarding demographic and clinical characteristics, diagnostic workup and management, was analyzed in International Business Machines (IBM) Statistics SPSS 21. Many statistical tests, such as t-test and the Mann-Whitney U test, were used. P < 0.05 was considered significant.

resultsWe identified 64 relevant articles. The mean age of the patients was 56 ± 16 years; the majority were males (64.9%). Among the neurological findings, paresthesia was the most typical symptom (48.9%). Most of the patients had been diagnosed by reverse transcriptase-polymerase chain reaction (RT-PCR) (69.2%). Two-third of the patients received immunoglobulins (IVIg) (77.7%). Although functions recovered in most patients, there were four patients with facial diplegia during follow-up (4.26%). Acute inflammatory demyelinating polyneuropathy (AIDP) was more likely to be associated with paresis of the lower extremity (p < 0.05) and higher levels of glucose on cerebrospinal fluid (CSF) analysis (p < 0.05). These patients were more likely to receive IVIg (p < 0.05) and develop respiratory insufficiency, subsequently (p < 0.05).

conclusionsGBS is being recognized as one of the many presentations of the COVID-19 infection. Although the common form is AIDP that might lead to complications, other variants are possible as well, and more studies are needed to focus on those subvariants.

Indexed as

COVID-19Guillain-Barre SyndromeHumansSARS-CoV-2Acute inflammatory demyelinating polyneuropathyCOVID-19Guillain-Barre syndromeMiller-Fisher syndrome

Identifiers

PMID33895700
PMCPMC8053360
OpenAlexW3156553414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.