ArticleJournal of chromatography. A2021
A method for the analysis of 121 multi-class environmental chemicals in urine by high-performance liquid chromatography-tandem mass spectrometry.
Article in Journal of chromatography. A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- Intra-individual variability of urinary non-persistent chemical concentrations during pregnancy in the ECHO Cohort.Journal of exposure science & environmental epidemiology · 2026Article
- Dietary guidelines adherence and pregnancy exposure to 10 classes of priority chemicals: an observational study in the Environmental influences on Child Health Outcomes Cohort.The American journal of clinical nutrition · 2026Observational
- Gestational Exposure to 10 Classes of Priority Chemicals and Birth Outcomes in the ECHO Cohort.JAMA network open · 2026Article
- SPE-UHPLC-MS/MS Method for Simultaneous Quantification of 50 Pesticide Biomarkers Across Nine Current-Use Chemical Classes in Human Urine.Journal of xenobiotics · 2026Article
- Racial and ethnic disparities in environmental chemical exposures and hypertensive disorders of pregnancy: The ECHO-wide cohort study.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Characterizing Prenatal Exposure to Contemporary and Emerging Chemicals in a Prospective Cohort of Pregnant Women in Atlanta, Georgia.Environment & health (Washington, D.C.) · 2026Article
- Psychosocial stressors as modifiers of the associations between well-studied and understudied chemicals and birth outcomes in the ECHO Cohort.Environmental pollution (Barking, Essex : 1987) · 2026Article
- A Streamlined Automated Liquid Handling and 96-Well Solid-Phase Extraction for Single Low-Volume Urine Aliquot Multiclass Biomarker Analysis in Human Biomonitoring.Environmental chemistry and ecotoxicology · 2026Article
- Review
- QuEChERS analytical approach for monitoring endocrine-disrupting chemicals in human urine.Analytical and bioanalytical chemistry · 2025Article
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Quantitative Exposomics Targeting over 200 Toxicants and Key Biomarkers at the Picomolar Level.Environmental science & technology · 2025Article
- Prenatal exposure to phthalates and alternative plasticizers and emotional and behavioral outcomes in early childhood in the Environmental influences on Child Health outcomes (ECHO) cohort.Environment international · 2025Article
- Exposures to Contemporary and Emerging Chemicals among Children Aged 2 to 4 Years in the United States Environmental Influences on the Child Health Outcome (ECHO) Cohort.Environmental science & technology · 2025Article
- An assessment of organophosphate ester mixtures and the placental transcriptome.Environment international · 2025Article
- Exploring the potential of MRM-IDA-EPI method in mass spectrometry for exposomic analysis: a commentary.Archives of toxicology · 2025Article
- Article
- Characterization of pesticide exposures and their associations with asthma morbidity in a predominantly low-income urban pediatric cohort in Baltimore City.Environmental research · 2024Article
- Scaling up a targeted exposome LC-MS/MS biomonitoring method by incorporating veterinary drugs and pesticides.Analytical and bioanalytical chemistry · 2024Article
- Screening for contamination levels of select organic environmental chemicals in medical supplies used for human specimen collection.Chemosphere · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Biomonitoring of human exposure to environmental chemicals has gained momentum in recent years. Biomonitoring methods often include analysis of a single class of chemicals with similar chemical properties. In this study, we describe a method that involves solid-phase extraction (SPE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) and capable of measuring 121 environmental chemicals comprising plasticizers (PMs; n = 45), environmental phenols (EPs; n = 45), and pesticides (n = 31) through a single extraction of urine. Urine samples were incubated with 20 µL of β-glucuronidase/arylsulfatase (4000 units/mL urine) (from Helix pomatia) buffered at pH 5.5 for 2 h at 37 °C for optimal deconjugation conditions. We compared two extraction methods, namely liquid-liquid extraction and SPE, and the latter with ABS Elut NEXUS® cartridges was optimized to yield best extraction efficiencies. For increased resolution and chromatographic separation, two methods involving Ultra AQ C18® and Betasil™ C18® columns were used. The MS/MS analyses were performed under both negative and positive ionization modes. The optimized method yielded excellent intra- and inter-day variabilities (relative standard deviation: 0.40-11%) and satisfactory recoveries (80-120%) for >95% of the analytes. The limits of detection were ≤ 0.1 ng/mL for 101 analytes and between 0.1 and 1.0 ng/mL for 18 analytes. The optimized SPE LC-MS/MS method was validated through the analysis of standard reference materials and proficiency test urine samples and further applied in the analysis of 21 real urine samples to demonstrate simultaneous determination of 121 environmental chemicals in urine samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.