Evidence map›Paper›PMID 33895426›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2021

COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin.

Tarab Mansoor, Ali A Alsarah, Hossein Mousavi, Javed Khader Eliyas, Tarun Girotra, Omar Hussein

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Cerebrovascular Manifestations of SARS-CoV-2: A Comprehensive Review.Current treatment options in neurology · 2023
    Review
  7. Reversible cerebral vasoconstriction syndrome: literature review.The Egyptian journal of neurology, psychiatry and neurosurgery · 2023
    Review
  8. Review
  9. Article
  10. Case report of a fulminant non-aneurysmal convexity subarachnoid hemorrhage after COVID-19.Interdisciplinary neurosurgery : Advanced techniques and case management · 2022
    Article
  11. Fulminant Reversible Cerebral Vasoconstriction Syndrome in Breakthrough COVID 19 Infection.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Article
  12. Reversible Cerebral Vasoconstriction Syndrome in Patients with Coronavirus Disease: A Multicenter Case Series.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
    Article
  13. Review
  14. Article
  15. Pathophysiology of SARS-CoV-2-associated ischemic stroke is variegated.The Egyptian journal of neurology, psychiatry and neurosurgery · 2021
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tarab MansoorUniversity of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Ali A AlsarahUniversity of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Hossein MousaviUniversity of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Javed Khader EliyasUniversity of New Mexico, Department of Neurosurgery, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Tarun GirotraUniversity of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA.
Omar HusseinUniversity of New Mexico, Department of Neurology, MSC10-5620, 1 UNM, Albuquerque, NM 87106, USA. Electronic address: ohussein@salud.unm.edu.
University of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There have been limited cases linking SARS-CoV-2 infection with the development of reversible cerebral vasoconstriction syndrome (RCVS). We hereby report a rare case of RCVS in the setting of mild SARS-CoV-2 respiratory infection successfully treated with nimodipine and aspirin. SARS-CoV-2 attacks the ACE2-receptors, which are expressed in various body organs including the lungs, kidneys, and blood vessels. Vasoconstriction can result from down-regulation of the ACE2-receptors that can lead to sympathetic hypertonia of the cerebral blood vessel walls and/or over-activation of the renin-angiotensin axis.

Indexed as

AdultAspirinCerebral ArteriesCOVID-19FemaleHumansNimodipineSyndromeTreatment OutcomeVasoconstrictionVasodilator AgentsVasospasm, IntracranialAspirinNimodipineVasodilator AgentsAspirinCOVID-19NimodipinePosterior reversible encephalopathy syndromeReversible cerebral vasoconstriction syndromeSARS-CoV-2

Identifiers

PMID33895426
PMCPMC8041144
OpenAlexW3156541075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.