Evidence map›Paper›PMID 33895226›Full record

ArticleThe Journal of infection2021

Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - A high risk community-hospital interface.

Kathy K Li, Y Mun Woo, Oliver Stirrup, Joseph Hughes, Antonia Ho, Ana Da Silva Filipe, Natasha Johnson, Katherine Smollett, Daniel Mair, Stephen Carmichael and 33 more

Abstract read
In one paragraph

Article in The Journal of infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Kathy K LiMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Y Mun WooThe Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK.
Oliver StirrupInstitute for Global Health, University College London, London, UK.
Joseph HughesMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Antonia HoMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Ana Da Silva FilipeMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Natasha JohnsonMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Katherine SmollettMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Daniel MairMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Stephen CarmichaelMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Lily TongMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Jenna NicholsMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Elihu Aranday-CortesMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Kirstyn BrunkerMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Yasmin A ParrMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Kyriaki NomikouMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Sarah E McDonaldMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Marc NiebelMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Patawee AsamaphanMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Vattipally B SreenuMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
David L RobertsonMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Aislynn TaggartMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Natasha JesudasonMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Rajiv ShahMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
James ShepherdMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Josh SingerMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Alison H M TaylorRenal Unit, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS, Canada.
Zoe CouslandRenal Unit, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS, Canada.
Jonathan PriceRenal Unit, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS, Canada.
Jennifer S LeesRenal Unit, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS, Canada; Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK.
Timothy P W JonesDepartment of Infectious Diseases, University Hospital Monklands, Monkscourt Ave, Airdrie ML60JS, Canada.
Carlos Varon LopezDepartment of Microbiology, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS, Canada.
Alasdair MacLeanWest of Scotland Specialist Virology Centre, Glasgow Royal Infirmary, UK.
Igor StarinskijWest of Scotland Specialist Virology Centre, Glasgow Royal Infirmary, UK.
Rory GunsonWest of Scotland Specialist Virology Centre, Glasgow Royal Infirmary, UK.
Scott T W MorrisThe Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK.
Peter C ThomsonThe Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK.
Colin C GeddesThe Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK.
Jamie P TraynorThe Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK.
Judith BreuerInstitute of Child Health University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.
Emma C ThomsonMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK; Department of Clinical Research, London School of Hygiene and Tropical Medicine, UK. Electronic address: Emma.Thomson@glasgow.ac.uk.
Patrick B MarkMRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH, UK; Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK. Electronic address: Patrick.Mark@glasgow.ac.uk.
COVID-19 Genomics UK (COG-UK) consortiumhttps://www.cogconsortium.uk, UK.

Funding

Medical Research Council MC_PC_19026Medical Research Council MC_PC_19027Medical Research Council MC_UU_12014/12Medical Research Council MC_UU_12014/9Wellcome Trust
6 · The paper itself

Abstract

objectivesPatients requiring haemodialysis are at increased risk of serious illness with SARS-CoV-2 infection. To improve the understanding of transmission risks in six Scottish renal dialysis units, we utilised the rapid whole-genome sequencing data generated by the COG-UK consortium.

methodsWe combined geographical, temporal and genomic sequence data from the community and hospital to estimate the probability of infection originating from within the dialysis unit, the hospital or the community using Bayesian statistical modelling and compared these results to the details of epidemiological investigations.

resultsOf 671 patients, 60 (8.9%) became infected with SARS-CoV-2, of whom 16 (27%) died. Within-unit and community transmission were both evident and an instance of transmission from the wider hospital setting was also demonstrated.

conclusionsNear-real-time SARS-CoV-2 sequencing data can facilitate tailored infection prevention and control measures, which can be targeted at reducing risk in these settings.

Indexed as

COVID-19SARS-CoV-2Bayes TheoremHospitalsHumansMolecular EpidemiologyRenal DialysisCOVID-19HaemodialysisInfection controlNosocomialOutbreakRapid sequencingRenal dialysis unitSARS-CoV-2

Identifiers

PMID33895226
PMCPMC8061788

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