ArticleOphthalmology2021
Persistent Opioid Use after Ophthalmic Surgery in Opioid-Naive Patients and Associated Risk Factors.
Article in Ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Prolonged opioid use after surgery in children, adolescents, and young adults: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Pooled it
- TFOS lifestyle: Impact of societal challenges on the ocular surface.The ocular surface · 2023Pooled it
- Dot Phrase Utilization and Opioid Prescription at Discharge for Subarachnoid Hemorrhage Patients.The Neurohospitalist · 2026Article
- Perioperative Opioid Use and Risk of Persistent Use After Common Otolaryngologic Procedures.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Effect of Oral Opioid Prescription on Rates of Postoperative Pain among Ophthalmology Subspecialties: A Large Database Analysis.Ophthalmology science · 2026Article
- Review
- Cornea specialists are the highest opioid prescribers at a large academic eye institute in the USA.BMJ open ophthalmology · 2025Article
- Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder.Genetic epidemiology · 2025Article
- Postoperative opioid use in Norway-a population-based observational study on patterns of long-term use.BMC pharmacology & toxicology · 2024Observational
- Risk factors for opioid use disorder after severe burns in adults.American journal of surgery · 2023Article
- Opioids Prescribing Among Patients with Zoster-Related Pain in Real-Life: A Retrospective, Cohort Study Based on the Clinical Database.Journal of pain research · 2023Article
- Psychiatric Comorbidities Associated with Persistent Postoperative Opioid Use.Current pain and headache reports · 2022Review
- Recent trends in anesthetic agents and techniques for ophthalmic anesthesia.Journal of anaesthesiology, clinical pharmacologyReview
- Association of Socioeconomic and Psychiatric Factors with Postoperative Opioid Use Disorder: A Retrospective Cohort Analysis.Substance use : research and treatmentArticle
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6 authors at 2 institutions in 1 country.
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Abstract
purposeTo determine the rate and risk factors for new persistent opioid use after ophthalmic surgery in the United States.
designRetrospective claims-based cohort analysis.
participantsOpioid-naive patients 13 years of age and older who underwent incisional ophthalmic surgery between January 1, 2012, and June 30, 2017, and were included in Optum's de-identified Clinformatics Data Mart database.
methodsNew persistent opioid use was defined as filling an opioid prescription in the 90-day and the 91- to 180-day periods after the surgical procedure. The outcome variable was an initial perioperative opioid prescription fill. Rates of new persistent opioid use were calculated, and multivariate logistic regression models were used to identify variables increasing the risk of new persistent use and refill of an opioid prescription after the initial perioperative prescription in first 30 days.
main outcome measuresNew persistent opioid use and refill.
resultsA total of 327 379 opioid-naive patients (mean age, 67 years [standard deviation, 16 years]; 178 067 women [54.4%]) who underwent ophthalmic surgery were examined. Among these patients, 14 841 (4.5%) had an initial perioperative opioid fill. The rate of new persistent opioid use was 3.4% (498 of 14 841 patients) compared with 0.6% (1833 of 312 538 patients) in patients who did not have an initial perioperative opioid fill. After adjusting for patient characteristics, initial perioperative opioid fill was associated independently with increased odds of new persistent use (adjusted odds ratio [OR], 6.21; 95% confidence interval [CI], 5.57-6.91; P < 0.001). Among patients who had filled an initial perioperative prescription, a prescription size of 150 morphine milligram equivalents or more was associated with an increased odds of refill (adjusted OR, 1.87; 95% CI, 1.58-2.22; P < 0.001).
conclusionsExposure to opioids in the perioperative period is associated with new persistent use in patients who were previously opioid-naive. This suggests that exposure to opioids is an independent risk factor for persistent use in patients undergoing incisional ophthalmic surgery. Surgeons should be aware of those risks to identify at-risk patients given the current national opioid crisis and to minimize prescribing opioids when possible.
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