Evidence map›Paper›PMID 33895141›Full record

ArticleThe Journal of biological chemistry

Sp1 is a substrate of Keap1 and regulates the activity of CRL4A

Ferbian Milas Siswanto, Ami Oguro, Susumu Imaoka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. CRL3Nature communications · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ferbian Milas SiswantoDepartment of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Japan.
Ami OguroDepartment of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Japan; Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Susumu ImaokaDepartment of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Japan. Electronic address: imaoka@kwansei.ac.jp.
Kwansei Gakuin University · JPHiroshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical transcription factor that orchestrates cellular responses to oxidative stress. Because the dysregulation of Nrf2 has been implicated in many diseases, precise regulation of its protein level is crucial for maintaining homeostasis. Kelch-like-ECH-associated protein 1 (Keap1) and WD40 repeat protein 23 (WDR23) directly regulate Nrf2 levels via similar but distinct proteasome-dependent pathways. WDR23 forms a part of the WDR23-Cullin 4A-RING ubiquitin ligase complex (CRL4A

Indexed as

Cell Line, TumorGene Expression RegulationHumansKelch-Like ECH-Associated Protein 1KineticsNF-E2-Related Factor 2Receptors, Interleukin-17Sp1 Transcription FactorUbiquitin-Protein LigasesIL17RB protein, humanKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2Receptors, Interleukin-17Sp1 Transcription FactorUbiquitin-Protein LigasesCullin4ACullin 4A-RING ligaseDNA damage-binding protein 1gene regulationKelch-like ECH-associated protein 1nuclear factor 2 (erythroid-derived 2-like factor)oxidative stressposttranslational regulationRing-box 1specificity protein 1WD40 repeat protein 23

Identifiers

PMID33895141
PMCPMC8141886
OpenAlexW3157104053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.