Evidence map›Paper›PMID 33895130›Full record

ArticleChest2021

Mitigation of Aerosols Generated During Exercise Testing With a Portable High-Efficiency Particulate Air Filter With Fume Hood.

Andrés Garzona-Navas, Pavol Sajgalik, Ibolya Csécs, J Wells Askew, Francisco Lopez-Jimenez, Alexander S Niven, Bruce D Johnson, Thomas G Allison

Open access · bronzeAbstract read
In one paragraph

Article in Chest, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Respiratory aerosol particle emission and simulated infection risk is greater during indoor endurance than resistance exercise.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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  6. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Andrés Garzona-NavasDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Pavol SajgalikExtreme Physiology Laboratory, Mayo Clinic, Rochester, MN.
Ibolya CsécsDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
J Wells AskewDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Francisco Lopez-JimenezDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Alexander S NivenDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Mayo Clinic, Rochester, MN.
Bruce D JohnsonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Extreme Physiology Laboratory, Mayo Clinic, Rochester, MN.
Thomas G AllisonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. Electronic address: allison.thomas@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of portable high-efficiency particulate air (HEPA) filters for supplemental aerosol mitigation during exercise testing is unknown and might be relevant during COVID-19 pandemic. RESEARCH QUESTION: What is the effect of portable HEPA filtering on aerosol concentration during exercise testing and its efficiency in reducing room clearance time in a clinical exercise testing laboratory? STUDY DESIGN AND

methodsSubjects were six healthy volunteers aged 20 to 56 years. In the first experiment, exercise was performed in a small tent with controlled airflow with the use of a stationary cycle, portable HEPA filter with fume hood, and particle counter to document aerosol concentration. Subjects performed a four-stage maximal exercise test that lasted 12 min plus 5 min of pretest quiet breathing and 3 min of active recovery. First, they exercised without mitigation then with portable HEPA filter running. In a separate experiment, room aerosol clearance time was measured in a clinical exercise testing laboratory by filling it with artificially generated aerosols and measuring time to 99.9% aerosol clearance with heating, ventilation, and air conditioning (HVAC) only or HVAC plus portable HEPA filter running.

resultsIn the exercise experiment, particle concentrations reached 1,722 ± 1,484/L vs 96 ± 124/L (P < .04) for all particles (>0.3 μm), 1,339 ± 1,281/L vs 76 ± 104/L (P < .05) for smaller particles (0.3 to 1.0 μm), and 333 ± 209/L vs 17 ± 19/L (P < .01) for larger particles (1.0 to 5.0 μm) at the end of the protocol in a comparison of mitigation vs portable HEPA filter. Use of a portable HEPA filter in a clinical exercise laboratory clearance experiment reduced aerosol clearance time 47% vs HVAC alone.

interpretationThe portable HEPA filter reduced the concentration of aerosols generated during exercise testing by 96% ± 2% for all particle sizes and reduced aerosol room clearance time in clinical exercise testing laboratories. Portable HEPA filters therefore might be useful in clinical exercise testing laboratories to reduce the risk of COVID-19 transmission.

Indexed as

Air FiltersPandemicsAdultAerosolsAir ConditioningCOVID-19FemaleHealthy VolunteersHumansMaleMiddle AgedParticle SizeYoung AdultAerosolsaerosolCOVID-19exercise testingHEPA filter

Identifiers

PMID33895130
PMCPMC8463654
OpenAlexW3158744927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.