Evidence map›Paper›PMID 33895084›Full record

ArticleTrends in biochemical sciences2021

How NS1 Antibodies Prevent Severe Flavivirus Disease.

Justin S G Ooi, Shee-Mei Lok

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in biochemical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Justin S G OoiProgramme in Emerging Infectious Disease, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Center for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
Shee-Mei LokProgramme in Emerging Infectious Disease, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Center for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117557, Singapore. Electronic address: sheemei.lok@duke-nus.edu.sg.
National University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The flavivirus genus consists of several major human pathogens including dengue (DENV) and Zika viruses. The flavivirus nonstructural protein 1 (NS1) plays an important role in disease progression, for example, in the development of severe dengue disease. Anti-NS1 antibodies have been shown to confer protection, and two new studies by Biering et al. and Modhiran et al. on the structure of NS1:antibody complexes reveal their mechanism of neutralization.

Indexed as

DengueDengue VirusFlavivirusZika VirusZika Virus InfectionAntibodies, ViralHumansViral Nonstructural ProteinsAntibodies, ViralViral Nonstructural Proteinsantibodyflavivirusnonstructural protein 1 (NS1)structural biology

Identifiers

PMID33895084
OpenAlexW3154893391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.