Evidence map›Paper›PMID 33894980›Full record

ArticleAmerican journal of surgery2022

Comparative outcomes between COVID-19 and influenza patients placed on veno-venous extracorporeal membrane oxygenation for severe ARDS.

Lauren A Raff, Trista D Reid, Daniel Johnson, Evan J Raff, Andrew B Schneider, Anthony G Charles, Jared R Gallaher

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in American journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  3. ECMO in COVID-19 Patients: A Systematic Review and Meta-analysis.Journal of cardiothoracic and vascular anesthesia · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lauren A RaffUniversity of North Carolina at Chapel Hill, Department of Surgery, Chapel Hill, NC, USA.
Trista D ReidUniversity of North Carolina at Chapel Hill, Department of Surgery, Chapel Hill, NC, USA.
Daniel JohnsonUniversity of North Carolina at Chapel Hill, Department of Surgery, Chapel Hill, NC, USA.
Evan J RaffUniversity of North Carolina at Chapel Hill, Department of Surgery, Chapel Hill, NC, USA.
Andrew B SchneiderUniversity of North Carolina at Chapel Hill, Department of Surgery, Chapel Hill, NC, USA.
Anthony G CharlesUniversity of North Carolina at Chapel Hill, Department of Surgery, Chapel Hill, NC, USA.
Jared R GallaherUniversity of North Carolina at Chapel Hill, Department of Surgery, Chapel Hill, NC, USA. Electronic address: jared_gallaher@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundECMO is an established supportive adjunct for patients with severe, refractory ARDS from viral pneumonia. However, the exact role and timing of ECMO for COVID-19 patients remains unclear.

methodsWe conducted a retrospective comparison of the first 32 patients with COVID-19-associated ARDS to the last 28 patients with influenza-associated ARDS placed on V-V ECMO. We compared patient factors between the two cohorts and used survival analysis to compare the hazard of mortality over sixty days post-cannulation.

resultsCOVID-19 patients were older (mean 47.8 vs. 41.2 years, p = 0.033), had more ventilator days before cannulation (mean 4.5 vs. 1.5 days, p < 0.001). Crude in-hospital mortality was significantly higher in the COVID-19 cohort at 65.6% (n = 21/32) versus 36.3% (n = 11/28, p = 0.041). The adjusted hazard ratio over sixty days for COVID-19 patients was 2.81 (95% CI 1.07, 7.35) after adjusting for age, race, ECMO-associated organ failure, and Charlson Comorbidity Index.

conclusionECMO has a role in severe ARDS associated with COVID-19 but providers should carefully weigh patient factors when utilizing this scarce resource in favor of influenza pneumonia.

Indexed as

AdultCOVID-19Extracorporeal Membrane OxygenationFemaleHospital MortalityHumansInfluenza, HumanMaleMiddle AgedRespiratory Distress SyndromeRetrospective StudiesSeverity of Illness IndexTreatment OutcomeCOVID-19Critical careECMOInfluenza

Identifiers

PMID33894980
PMCPMC8056852
OpenAlexW3152942920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.