Evidence map›Paper›PMID 33894740›Full record

Observational studyBMC cardiovascular disorders2021

Effects of peak time of myocardial injury biomarkers on mid-term outcomes of patients undergoing OPCABG.

Bo Hu, Fei Gao, Mengwei Lv, Ban Liu, Yu Shi, Xi Chen, Yipeng Feng, Xiaoqi Meng, Zhi Li, Yangyang Zhang

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Bo Hu *Department of Cardiology, Shanghai East Hospital, School of Medicine,Tongji University, Shanghai, China.
Fei Gao *Cardiovascular Department, Huaiyin Hospital of Huai'an City, Huai'an, China.
Mengwei Lv *Shanghai East Hospital of Clinical Medical College, Nanjing Medical University, Shanghai, China.
Ban LiuDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine,Tongji University, Shanghai, China.
Yu ShiDepartment of Cardiovascular Surgery, Shanghai East Hospital, School of Medicine,Tongji University, 150 Jimo Road, Shanghai, 200120, China.
Xi ChenDepartment of Cardiovascular Surgery, Shanghai East Hospital, School of Medicine,Tongji University, 150 Jimo Road, Shanghai, 200120, China.
Yipeng FengThe First Clinical Medical College of Nanjing Medical University, Nanjing, China.
Xiaoqi MengThe Second Clinical Medical College of Nanjing Medical University, Nanjing, China.
Zhi LiDepartment of Cardiovascular Surgery, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China. zhili_cths@163.com.
Yangyang ZhangDepartment of Cardiovascular Surgery, Shanghai East Hospital, School of Medicine,Tongji University, 150 Jimo Road, Shanghai, 200120, China. zhangyangyang_wy@vip.sina.com.
Shanghai East Hospital · CNNanjing Medical University · CNSecond Affiliated Hospital of Nanjing Medical University · CNSecond People’s Hospital of Huai’an · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith the development of cardiac surgery techniques, myocardial injury is gradually reduced, but cannot be completely avoided. Myocardial injury biomarkers (MIBs) can quickly and specifically reflect the degree of myocardial injury. Due to various reasons, there is no consensus on the specific values of MIBs in evaluating postoperative prognosis. This retrospective study was aimed to investigate the impact of MIBs on the mid-term prognosis of patients undergoing off-pump coronary artery bypass grafting (OPCABG).

methodsTotally 564 patients undergoing OPCABG with normal courses were included. Cardiac troponin T (cTnT) and creatine kinase myocardial band (CK-MB) were assessed within 48 h before operation and at 6, 12, 24, 48, 72, 96 and 120 h after operation. Patients were grouped by peak values and peak time courses of MIBs. The profile of MIBs and clinical variables as well as their correlations with mid-term prognosis were analyzed by univariable and multivariable Cox regression models.

resultContinuous assessment showed that MIBs increased first (12 h after surgery) and then decreased. The peak cTnT and peak CK-MB occurred within 24 h after operation in 76.8% and 67.7% of the patients respectively. No significant correlation was found between CK-MB and mid-term mortality. Delayed cTnT peak (peak cTnT elevated after 24 h after operation) was correlated with lower creatinine clearance rate (69.36 ± 21.67 vs. 82.18 ± 25.17 ml/min/1.73 m

conclusioncTnT is a better indicator than CK-MB. The peak value and peak occurrence of cTnT are related to mid-term mortality in patients undergoing OPCABG, and the peak phases have stronger predictive ability.

trial registrationChinese Clinical Trial Registry, ChiCTR2000033850. Registered 14 June 2020, http://www.chictr.org.cn/edit.aspx?pid=55162&htm=4 .

Indexed as

AgedBiomarkersCoronary Artery Bypass, Off-PumpCreatine Kinase, MB FormFemaleHeart InjuriesHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeTroponin TBiomarkersCreatine Kinase, MB FormTroponin TCoronary artery bypass graftingMid-term outcomeMyocardial injury biomarkerOff pump

Identifiers

PMID33894740
PMCPMC8066968
OpenAlexW3135892679

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.