ArticleNeurobiology of aging2021
Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03389100 (Tau Positron Emission Tomography), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tau Positron Emission Tomography (PET) Imaging in the Northern Manhattan Study of Metabolism and Mind (NOMEM) With 18F-MK6240.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Elevated temporal tau PET predicts faster cognitive decline in women than men: A meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E ε4 in an Admixed Autopsy Sample.JAMA neurology · 2026Article
- Sex Differences in Alzheimer Disease Imaging Biomarkers in a Diverse, Community-Based Cohort.JAMA network open · 2026Article
- Article
- Midlife Steroid-Binding Globulin Levels and In Vivo Neuroimaging Measures of Tau in Older Men and Women.Annals of neurology · 2025Article
- Sex differences in amyloid PET in a large, real-world sample from the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Increased between-network connectivity: A risk factor for tau elevation and disease progression.Neuroscience letters · 2024Article
- ERRα and ERRγ coordinate expression of genes associated with Alzheimer's disease, inhibitingProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies.NPJ Parkinson's disease · 2024Article
- Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Review
- Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Minding the Gap: Exploring Neuroinflammatory and Microglial Sex Differences in Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Age-, sex-, and pathology-related variability in brain structure and cognition.Translational psychiatry · 2023Article
- Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease.Nature medicine · 2023Article
- Article
- Menopause Status Moderates Sex Differences in Tau Burden: A Framingham PET Study.Annals of neurology · 2022Article
- A guide for researchers seeking training in retrospective data harmonization for population neuroscience studies of Alzheimer's disease and related dementias.Frontiers in neuroimaging · 2022Article
- Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females.Neurobiology of aging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Priya PaltaDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: pp2464@cumc.columbia.edu.
Brady RipponDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Mouna TahmiDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Michelle PardoDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Aubrey JohnsonDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Zeljko TomljanovicDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Hengda HeDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Krystal K LaingDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Qolamreza R RazlighiDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA; Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Jeanne A TeresiColumbia University Stroud Center at New York State Psychiatric Institute, New York, NY and Research Division, Hebrew Home in Riverdale, Bronx, NY, USA.
Herman MorenoColumbia University Stroud Center at New York State Psychiatric Institute, New York, NY and Research Division, Hebrew Home in Riverdale, Bronx, NY, USA.
Adam M BrickmanDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA.
William C KreislDepartment of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA; Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
José A LuchsingerDepartment of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Columbia University · USColumbia University Irving Medical Center · USSUNY Downstate Health Sciences University · USHebrew Home · US
Funding
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MMetformin in Alzheimer's dementia Prevention (MAP)R01AG062624 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HANLEY, DANIEL F, LUCHSINGER, JOSE ALEJANDRO · 2019 to 2025
$37.8MResearch Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Andrew Franklin Teich · 2020 to 2026
$30.1MResiding in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ORNA INTRATOR · 2010 to 2026
$21.9MDiabetes Status and Brain Amyloid in Middle Aged HispanicsR01AG050440 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LUCHSINGER, JOSE ALEJANDRO · 2015 to 2025
$21.9MPilot CoreP30AG022845 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Manney Carrington Reid · 2003 to 2026
$15.2MInterdisciplinary Research to Understand the Interplay of Diabetes, Cerebrovascular disease and Alzheimers diseaseRF1AG051556 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, LUCHSINGER, JOSE ALEJANDRO · 2015 to 2019
$9.7MAre there ethnic differences in brain amyloid and tau in the seventh decade of life?R01AG055299 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LUCHSINGER, JOSE ALEJANDRO · 2017 to 2022
$7.4MResearch Education CoreP30AG059303 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ADAM M BRICKMAN, Jennifer Jaie Manly · 2018 to 2026
$6.0MMidcareer Award for Research in Dementia Risk Factors and PreventionK24AG045334 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jose Alejandro Luchsinger · 2016 to 2026
$1.5MPhysical Activity and Preservation of Cognitive FunctionR00AG052830 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PALTA, PRIYA · 2019 to 2021
$1.1MNCATS NIH HHS UL1 TR001873NIA NIH HHS K24 AG045334NIA NIH HHS P30 AG022845NIA NIH HHS P30 AG028741NIA NIH HHS P30 AG059303NIA NIH HHS P30 AG066462NIA NIH HHS R00 AG052830NIA NIH HHS R01 AG050440NIA NIH HHS R01 AG055299NIA NIH HHS R01 AG062624NIA NIH HHS RF1 AG051556
Abstract
It is unclear whether women have higher brain tau pathology. The objective of this study was to examine whether women have higher tau burden than men, and whether tau differences are independent of amyloid β (Aβ) burden. We conducted a cross-sectional analysis of a multiethnic sample of 252 nondemented late middle-aged (mean age: 64.1 years) adults with tau and amyloid Positron Emission Tomography (PET) data. Tau burden was measured as global standardized uptake value ratio (SUVR) in the middle/inferior temporal gyri and medial temporal cortex with
Indexed as
Sex CharacteristicsAgedAmyloid beta-PeptidesBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedNeuroimagingPositron-Emission TomographySex FactorsTauopathiestau ProteinsTemporal LobeAmyloid beta-PeptidesBiomarkerstau ProteinsAlzheimer's diseaseEpidemiologyNeuroimagingSex differences
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT03389100ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.