Trial reportBehaviour research and therapy2021
Changes in neural reward processing following Amplification of Positivity treatment for depression and anxiety: Preliminary findings from a randomized waitlist controlled trial.
Trial report in Behaviour research and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Positive Valence System Enhancement Treatment for Anxiety and Depression: Clinical Efficacy and Neural Changes
Evaluation of an Online Intervention Targeting Depression and Low Reward Sensitivity - A Randomized Controlled Trial
Developing and Evaluating a Positive Valence Treatment for Alcohol Use Disorder With Anxiety or Depression
Decoding Emotional Dynamics Driving Mood Instability in Bipolar Disorder
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Examining the relationship between pre-treatment anhedonia and treatment outcomes in individuals with anxiety or depression: A systematic review.Journal of affective disorders · 2026Pooled it
- Behavioral and electrophysiological evidence of reward processing deficits in repetitive negative thinking: Implications for depression.Psychological medicine · 2026Trial
- Brain Activation Associated With Response to Psychotherapies for Late-Life Depression: A Task-Based fMRI Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Trial
- Amplification of positivity for depression and anxiety: Neural prediction of treatment response.Behaviour research and therapy · 2024Trial
- Positive affect treatment targets reward sensitivity: A randomized controlled trial.Journal of consulting and clinical psychology · 2023Trial
- Blunted Reward Responsiveness During Social Feedback: Associations with Peer Victimization and Anhedonia in Socially Anxious Adolescents.Brain and behavior · 2026Article
- Phase synchronization alterations of EEG oscillations during emotional video processing in depression and anxiety: a transdiagnostic study.European archives of psychiatry and clinical neuroscience · 2026Article
- Deep learning identification of reward-related neural substrates of preadolescent irritability: A novel 3D CNN application for fMRI.Neuroimage. Reports · 2025Article
- Article
- Inclusion of Individuals With Lived Experiences in the Development of a Digital Intervention for Co-Occurring Depression and Cannabis Use: Mixed Methods Investigation.JMIR formative research · 2024Article
- Hooking the Self Onto the Past: How Positive Autobiographical Memory Retrieval Benefits People With Social Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
- Reward processes in extinction learning and applications to exposure therapy.Journal of anxiety disorders · 2024Review
- Anhedonia influences threat avoidance and relief: A conceptual replication.Journal of mood and anxiety disorders · 2024Article
- Improving social reward responsivity and social connectedness in psychotherapies for late-life depression: Engage & Connect as an example.Psychiatry research · 2023Article
- [Late-life depression and frailty-Epidemiological, clinical and neurobiological associations].Der Nervenarzt · 2023Review
- AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale.BMC psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Positive valence system (PVS) deficits are increasingly recognized as important treatment targets for depression and anxiety. Emerging behavioral treatments designed to upregulate the PVS show initial promise; however, neural mechanisms underlying these approaches remain unknown. This study investigated neural reward-processing-related changes following Amplification of Positivity (AMP)-a treatment designed to enhance positive thinking, emotions and behaviors through positive activity interventions (Clinicaltrials.gov: NCT02330627). Individuals with depression and/or anxiety (N = 29) were randomized to 10 sessions of AMP (n = 16) or waitlist (WL; n = 13). Participants completed a monetary incentive delay task during fMRI at baseline and post-assessment. Hypothesis-driven region of interest (ventral striatum, insula, anterior cingulate) and exploratory whole-brain activation and connectivity analyses evaluated pre-to-post changes for AMP vs. WL when anticipating potential monetary gain or loss. No between-group brain activation changes emerged in regions of interest or whole-brain analyses. Increased neural connectivity from pre-to-post-treatment was observed in AMP vs. WL, including ventral striatum, anterior insula, and anterior cingulate connectivity with prefrontal, limbic, occipital and parietal regions-predominantly during loss anticipation. This preliminary study is the first to examine neural mechanisms of positive activity interventions in depression and anxiety and suggests that AMP may strengthen brain connectivity in reward processing, attention, and emotion regulation networks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.