Evidence map›Paper›PMID 33894411›Full record

ArticleBiochemical and biophysical research communications2021

Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung.

Koichi Yuki, Yusuke Mitsui, Miho Shibamura-Fujiogi, Lifei Hou, Kirsten C Odegard, Sulpicio G Soriano, Gregory P Priebe, Sophia Koutsogiannaki

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Effects of anesthesia with sevoflurane on outcome parameters in murine experimental studies.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
  3. Article
  4. Propofol directly binds to and inhibits TLR7.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  5. Isoflurane attenuates sepsis-associated lung injury.Biochemical and biophysical research communications · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Koichi YukiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA. Electronic address: Koichi.yuki@childrens.harvard.edu.
Yusuke MitsuiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.
Miho Shibamura-FujiogiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA.
Lifei HouDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA.
Kirsten C OdegardDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.
Sulpicio G SorianoDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.
Gregory P PriebeDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.
Sophia KoutsogiannakiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA. Electronic address: Sophia.koutsogiannaki@childrens.harvard.edu.
Boston Children's Hospital · US

Funding

Optimization of anesthetic/sedative regimen for pulmonary pathophysiology in cystic fibrosis patientsR21AI158886 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI YUKI, KOICHI · 2021 to 2022
$487k
NIAID NIH HHS R21 AI158886
6 · The paper itself

Abstract

Isoflurane and sevoflurane are volatile anesthetics (VA) widely used in clinical practice to provide general anesthesia. We and others have previously shown that VAs have immunomodulatory effects and may have a significant impact on the progression of disease states. Flagellin is a component of Gram negative bacteria and plays a significant role in the pathophysiology of bacterial pneumonia through its binding to Toll-like Receptor 5 (TLR5). Our results showed that VAs, not an intravenous anesthetic, significantly attenuated the activation of TLR5 and the release of the neutrophil chemoattractant IL-8 from lung epithelial cells. Furthermore, flagellin-induced lung injury was significantly attenuated by VAs by inhibiting neutrophil migration to the bronchoalveolar space. The lungs of cystic fibrosis (CF) patients are highly colonized by Pseudomonas aeruginosa, which causes inflammation. The retrospective study of oxygenation in patients with CF who had received VA versus intravenous anesthesia suggested that VAs might have the protective effect for gas exchange. To understand the interaction between VAs and TLR5, a docking simulation was performed, which indicated that isoflurane and sevoflurane docked into the binding interphase between TLR5 and flagellin.

Indexed as

Anesthetics, InhalationAnimalsCell Line, TumorCystic FibrosisEpithelial CellsFemaleFlagellinHumansInflammationInflammation MediatorsInterleukin-8IsofluraneLungMaleMiceMolecular Docking SimulationAnesthetics, InhalationFlagellinInflammation MediatorsInterleukin-8IsofluraneNF-kappa BSevofluraneTLR5 protein, humanToll-Like Receptor 5Cystic fibrosisFlagellinToll-like receptor 5Volatile anesthetics

Identifiers

PMID33894411
PMCPMC8113123
OpenAlexW3154443728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.