Evidence map›Paper›PMID 33894315›Full record

ArticleFitoterapia2021

Discovery of naturally occurring inhibitors against SARS-CoV-2 3CL

Yuan Xiong, Guang-Hao Zhu, Hao-Nan Wang, Qing Hu, Li-Li Chen, Xiao-Qing Guan, Hui-Liang Li, Hong-Zhuan Chen, Hui Tang, Guang-Bo Ge

Open access · greenAbstract read
In one paragraph

Article in Fitoterapia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
  2. Uncovering the covalent inhibitors of SARS-CoV-2 MJournal of pharmaceutical analysis · 2026
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  18. Informatics in medicine unlocked · 2023
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yuan XiongKey Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Pharmacy School of Shihezi University, Xinjiang, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Guang-Hao ZhuInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hao-Nan WangInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qing HuInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li-Li ChenInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xiao-Qing GuanInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hui-Liang LiSchool of Pharmacy, Second Military Medical University, Shanghai, China.
Hong-Zhuan ChenInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hui TangKey Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Pharmacy School of Shihezi University, Xinjiang, China. Electronic address: th_pha@shzu.edu.cn.
Guang-Bo GeInstitute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: geguangbo@dicp.ac.cn.
Shanghai University of Traditional Chinese Medicine · CNSecond Military Medical University · CNShihezi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3-Chymotrypsin-like protease (3CL

Indexed as

COVID-19 Drug TreatmentAntiviral AgentsBiflavonoidsCoronavirus Protease InhibitorsFlavonesGinkgo bilobaHumansMolecular StructurePhytotherapyPlant ExtractsPlant LeavesSalicylatesSARS-CoV-2Virus ReplicationAntiviral AgentsBiflavonoidsCoronavirus Protease InhibitorsflavoneFlavonesginkgolic acidPlant ExtractsSalicylatessciadopitysinBioflavonesGinkgo biloba leavesGinkgolic acidsInhibitory mechanismSARS-CoV-2 3CL(pro)

Identifiers

PMID33894315
PMCPMC8061081
OpenAlexW3156608464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.