ArticleJournal of magnetic resonance imaging : JMRI2021
Quantitative 3D Ultrashort Echo Time Magnetization Transfer Imaging for Evaluation of Knee Cartilage Degeneration In Vivo.
Article in Journal of magnetic resonance imaging : JMRI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Ultrashort echo time bi-component analysis of tibiotalar articular cartilage after long-distance running.European radiology · 2026Article
- Ultrashort echo time quantitative magnetization transfer MRI detects non-enzymatic crosslinking of collagen in ex vivo rat bones.JBMR plus · 2026Article
- Quantitative Ultrashort Echo Time Magnetization Transfer Imaging of the Osteochondral Junction: An In Vivo Knee Osteoarthritis Study.Journal of imaging · 2025Article
- Quantitative magnetic resonance imaging in Alzheimer's disease: a narrative review.Quantitative imaging in medicine and surgery · 2025Review
- Non-invasive evaluation of Achilles tendon and its enthesis using ultrashort echo time adiabatic TEuropean journal of radiology · 2025Article
- UTE MRI technical developments and applications in osteoporosis: a review.Frontiers in endocrinology · 2025Review
- Achilles tendon and enthesis assessment using ultrashort echo time magnetic resonance imaging (UTE-MRI) T1 and magnetization transfer (MT) modeling in psoriatic arthritis.NMR in biomedicine · 2024Article
- The effect of cartilage dehydration and rehydration on quantitative ultrashort echo time biomarkers.Quantitative imaging in medicine and surgery · 2023Article
- Review
- Ultrashort echo time magnetic resonance imaging of the osteochondral junction.NMR in biomedicine · 2023Review
- Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications.Applied physics reviews · 2022Review
- Preliminary study on the assessment of early cartilage degeneration by quantitative ultrashort echo time magnetic resonance imagingQuantitative imaging in medicine and surgery · 2022Article
- Ultrashort Echo Time Magnetic Resonance Imaging Techniques: Met and Unmet Needs in Musculoskeletal Imaging.Journal of magnetic resonance imaging : JMRI · 2022Review
- Articular Cartilage Assessment Using Ultrashort Echo Time MRI: A Review.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRecent studies suggest that macromolecular fraction (MMF) derived from three-dimensional ultrashort echo time magnetization transfer (UTE-MT) imaging is insensitive to the magic angle effect. However, its clinical use in osteoarthritis (OA) remains to be investigated. PURPOSE: To investigate the feasibility of 3D UTE-MT-derived MMF in differentiating normal from degenerated cartilage. STUDY TYPE: Prospective. SUBJECTS: Sixty-two participants (54.8 ± 16.7 years, 30 females) with and without OA, plus two healthy volunteers (mean age 35.0 years) for reproducibility test. FIELD STRENGTH/SEQUENCE: 3 T/UTE-MT sequence. ASSESSMENT: A 3D UTE-MT sequence was employed to calculate MMF based on a two-pool model. Kellgren-Lawrence (KL) grade and Whole-Organ Magnetic Resonance Imaging Score (WORMS) were evaluated by three experienced musculoskeletal radiologists. KL grade was condensed into three groups: KL0, KL1-2, and KL3-4. WORMS was regrouped based on extent of lesion (extent group) and depth of lesion (depth group), respectively. The performance of MMF at evaluating the degeneration of cartilage was assessed via Spearman's correlation coefficient and the area under the curve (AUC) calculated according to the receiver-operating characteristic curve. STATISTICAL TESTS: After normality check, one-way analysis of variance was used to evaluate the performance. Tukey-Kramer test was performed for post hoc testing.
resultsMMF showed significant negative correlations with KL grade (r = -0.53, P < 0.05) and WORMS (r = -0.49, P < 0.05). Significantly lower MMFs were found in subjects with greater KL grade (11.8 ± 0.8% for KL0; 10.9 ± 0.9% for KL1-2; 10.6 ± 1.1% for KL3-4; P < 0.05) and in cartilage with greater extent (12.1 ± 1.6% for normal cartilage; 10.9 ± 1.6% for regional lesions; 9.6 ± 1.7% for diffuse lesions; P < 0.05) and depth (12.1 ± 1.6% for normal cartilage; 10.6 ± 1.6% for partial-thickness lesions; 8.8 ± 1.7% for full-thickness lesions; P < 0.05) of lesions. AUC values of MMF for doubtful-minimal OA (KL1-2) and mild cartilage degradation (WORMS1-2) were 0.8 and 0.7, respectively. DATA
conclusionThis study highlights the clinical potential of MMF in the detection of early OA. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.