ArticleEuropean journal of neurology2021
Dementia increases mortality beyond effects of comorbid conditions: A national registry-based cohort study.
Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Mortality of people with diagnosed dementia in Germany between 2016 and 2021.Alzheimer's research & therapy · 2026Article
- Alzheimer's disease and related dementias state policies and mortality in the United States: A descriptive study.Journal of Alzheimer's disease : JAD · 2026Article
- Predicting All-Cause Mortality Using Two Claims-Based Measures in Medicare Beneficiaries With Dementia.Medical care research and review : MCRR · 2026Article
- Experiences of Formal and Informal Support Among Adult-Daughter Caregivers of People With Dementia in Sweden: A Qualitative Study.Dementia (London, England) · 2026Article
- Leveraging electronic health records to examine differential clinical outcomes in people with Alzheimer's disease.Communications medicine · 2026Article
- Biosacetalin (1,1-Diethoxyethane) Improves Healthy Lifespan inAntioxidants (Basel, Switzerland) · 2026Article
- Effects of extreme heat on the onset of dementia and all-cause mortality: A 3-year follow-up study in a large population-based cohort in Japan.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Ageing populations: new challenges in longevity.BMC public health · 2025Article
- Association between long-term healthy aging trajectories and all-cause mortality among middle-aged and older adults.Archives of public health = Archives belges de sante publique · 2025Article
- [Dementia(associated) deaths in Bavaria-analysis of comorbidities based on multiple cause of death statistics from 2020 to 2022].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025Article
- Multimorbidity in dementia: Current perspectives and future challenges.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Challenges in managing comorbidities among people with dementia in low- and middle-income countries.Neurodegenerative disease management · 2025Article
- Using electronic health records to understand multimorbidity in older people: a scoping review.European geriatric medicine · 2025Article
- The Effect of Influenza Vaccination on Hospitalization and Mortality Among People With Dementia.Journal of the American Geriatrics Society · 2025Article
- The Impact of Comorbid Dementia and Diabetes Mellitus on Hospital Patients' Outcomes: A Systematic Review and Meta-analysis.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- External Validation of the Charlson Comorbidity Index-based Model for Survival Prediction in Thai Patients Diagnosed with Dementia.BMC geriatrics · 2024Article
- In-Hospital Mortality in Patients with and without Dementia across Age Groups, Clinical Departments, and Primary Admission Diagnoses.Brain sciences · 2024Article
- Association of periodontal disease treatment with mortality in patients with dementia: a population-based retrospective cohort study (2002-2018).Scientific reports · 2024Article
- Dementia and mortality in older adults: A twin study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMortality is known to be markedly increased in people with dementia. However, the association between multiple chronic conditions and mortality in dementia is not well clarified. The aim of this study was to investigate the impact of somatic and psychiatric diseases on mortality in dementia compared with the general elderly population.
methodsUsing a cohort study design, nationwide registry data from 2006 to 2015 on dementia and psychiatric and somatic comorbidities defined by the Charlson Comorbidity Index (CCI) were linked. Impact of chronic conditions was assessed according to mortality rate ratios (MRRs) in all Danish residents aged ≥65 years with and without dementia.
resultsOur population comprised 1,518,917 people, of whom 114,109 people were registered with dementia. The MRRs was 2.70 (95% confidence interval 2.68, 2.72) in people with dementia after adjusting for sex, age, calendar year, and comorbidities. MRRs increased with higher CCI score, and when comparing people with a similar comorbidity load, MRRs were significantly higher for people with dementia.
conclusionsThe comorbidity load was associated with increased mortality in both people with and without dementia. Mortality in dementia remained increased, even after adjusting for psychiatric and chronic somatic comorbidities. Our findings suggest that dementia disorders alone contribute to excess mortality, which may be further increased by comorbidities.
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