ArticleActa psychiatrica Scandinavica2021
Severe mental illness is associated with increased mortality and severe course of COVID-19.
Article in Acta psychiatrica Scandinavica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 6 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Respiratory disease in people with bipolar disorder: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Strengthening the delivery of integrated physical health care for adults experiencing serious mental illness: a scoping review of interventions in mental health settings.Frontiers in health services · 2025Pooled it
- COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses.Epidemiology and psychiatric sciences · 2023Pooled it
- Pharmacokinetic Markers of Clinical Outcomes in Severe Mental Illness: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Clozapine Therapy and COVID-19: A Systematic Review of the Prevalence Rates, Health Outcomes, Hematological Markers, and Patient Perspectives.Schizophrenia bulletin · 2023Pooled it
- Mortality from coronavirus disease 2019 (Covid-19) in patients with schizophrenia: A systematic review, meta-analysis and meta-regression.General hospital psychiatryPooled it
- SARS-CoV-2 seroprevalence among patients with severe mental illness: A cross-sectional study.PloS one · 2022Trial
- Mortality Risks in Patients With Schizophrenia in Shanghai: A Longitudinal Cohort Study.Actas espanolas de psiquiatria · 2026Article
- A psychotic dilemma: psychodynamic group therapy for patients with schizophrenia in times of crisis.Frontiers in psychology · 2026Article
- Modeling the Role of Baseline Risk and Additional Study-Level Covariates in Meta-Analysis of Treatment Effects.Statistics in medicine · 2025Article
- Protective effects of psychiatric medications against COVID-19 mortality before vaccines.PloS one · 2025Article
- Perspectives regarding COVID-19 vaccination among unvaccinated persons with mental illness.Industrial psychiatry journal · 2024Article
- The anxiety response of patients with severe psychiatric disorders to the recent public health crisis.BMC psychiatry · 2024Article
- COVID-19-Related Outcomes Among Group Home Residents with Serious Mental Illness in Massachusetts in the First Year of the Pandemic.Administration and policy in mental health · 2024Article
- Mental health and risk of death and hospitalization in COVID-19 patients. Results from a large-scale population-based study in Spain.PloS one · 2024Article
- Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990-2019.Diseases (Basel, Switzerland) · 2023Article
- The impact of preexisting psychiatric disorders and antidepressant use on COVID-19 related outcomes: a multicenter study.Molecular psychiatry · 2023Article
- Impact of COVID-19 on mental health in Bhutan: a way forward for action.The Lancet regional health. Southeast Asia · 2023Review
- Review
- COVID-19 and Mental illness: perceptions of the pandemic and adherence to pandemic public health measures.Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2022Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePsychiatric disorders have been associated with unfavourable outcome following respiratory infections. Whether this also applies to coronavirus disease 2019 (COVID-19) has been scarcely investigated.
methodsUsing the Danish administrative databases, we identified all patients with a positive real-time reverse transcription-polymerase chain reaction test for COVID-19 in Denmark up to and including 2 January 2021. Multivariable cox regression was used to calculate 30-day absolute risk and average risk ratio (ARR) for the composite end point of death from any cause and severe COVID-19 associated with psychiatric disorders, defined using both hospital diagnoses and redemption of psychotropic drugs.
resultsWe included 144,321 patients with COVID-19. Compared with patients without psychiatric disorders, the standardized ARR of the composite outcome was significantly increased for patients with severe mental illness including schizophrenia spectrum disorders 2.43 (95% confidence interval [CI], 1.79-3.07), bipolar disorder 2.11 (95% CI, 1.25-2.97), unipolar depression 1.70 (95% CI, 1.38-2.02), and for patients who redeemed psychotropic drugs 1.70 (95% CI, 1.48-1.92). No association was found for patients with other psychiatric disorders 1.13 (95% CI, 0.86-1.38). Similar results were seen with the outcomes of death or severe COVID-19. Among the different psychiatric subgroups, patients with schizophrenia spectrum disorders had the highest 30-day absolute risk for the composite outcome 3.1% (95% CI, 2.3-3.9%), death 1.2% (95% CI, 0.4-2.0%) and severe COVID-19 2.7% (95% CI, 1.9-3.6%).
conclusionSchizophrenia spectrum disorders, bipolar disorder, unipolar depression and psychotropic drug redemption are associated with unfavourable outcomes in patients with COVID-19.
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