ArticleNeurology and therapy2021
The Association Between Dietary Acid Load and Odds of Migraine: A Case-Control Survey.
Article in Neurology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Dietary Patterns on Migraine Management: Mechanisms of Action and Recent Literature Insights.Brain and behavior · 2025Pooled it
- The association between dietary acid load and endometriosis: a case-control study.BMC women's health · 2026Article
- Association of diet quality, dietary acid load and antioxidant index with migraine severity, disability, and duration: a cross-sectional study.BMC neurology · 2026Article
- Healthy eating index 2015 might be associated with migraine headaches: Results from a Case-Control study.Food science & nutrition · 2024Article
- Dietary acid load and markers of malnutrition, inflammation, and oxidative stress in hemodialysis patients.Frontiers in nutrition · 2024Article
- Dietary acid load, depression, and anxiety: results of a population-based study.BMC psychiatry · 2023Article
- Higher Dietary Acid Load Might Be a Potent Derivative Factor for Multiple Sclerosis: The Results from a Case-Control Study.Nutrients · 2023Article
- Dietary acid load, alternative healthy eating index score, and bacterial vaginosis: is there any association? A case-control study.BMC infectious diseases · 2022Article
- Association between dietary acid load and clinical features of migraine headaches among Iranian individuals.Scientific reports · 2022Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionIt has been shown that a high acid load in the human body can affect inflammatory factors and the nitric oxide pathway. These factors are also thought to play an important role in the initiation of migraine attacks. We have therefore explored the association between dietary acid load and odds of migraine in a case-control study.
methodsThe migraine group (n = 514, diagnosed according to the International Classification of Headache Disorders 3rd edition [ICHDIII] criteria) was recruited from a tertiary headache clinic. The controls consisted of 582 sex-matched healthy volunteers who were randomly selected from the general population. A validated 168-item semiquantitative food frequency questionnaire was used for dietary intake assessments. Estimation of the dietary acid load was performed using three different measures: potential renal acid load (PRAL) score, net endogenous acid production (NEAP) score, and protein/potassium ratio.
resultsMultivariable logistic regression analysis showed that, in comparison with the lowest tertile, the highest tertile of dietary acid load measures, including PRAL (odds ratio [OR] 7.208, 95% confidence intervals [CI] 3.33-15.55), and NEAP (OR 4.108, 95% CI 1.924-8.774) scores and the protein/potassium ratio (OR 4.127, 95% CI 1.933-8.814), significantly increased the odds of migraine (P value for trend ≤ 0.001).
conclusionIn this study, high dietary acid load was associated with higher odds of migraine. It is therefore possible that restricting dietary acid load could reduce the odds of migraine in susceptible subjects. However, due to the preliminary nature of the current evidence, caution is advised in drawing a definitive conclusion. More well-designed studies are required for a better understanding of this important issue.
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