Evidence map›Paper›PMID 33893962›Full record

ArticleBulletin of experimental biology and medicine2021

Reduced Expression of Extracellular Matrix Proteins in the Heart and Kidneys of Rats with Endotoxemia under the Effect of Actinonin.

D A Chepurnova, E V Samoilova, А G Fesenko, А А Korotaeva

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

D A ChepurnovaNational Medical Research Center for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
E V SamoilovaNational Medical Research Center for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia. erihter@mail.ru.
А G FesenkoNational Medical Research Center for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
А А KorotaevaNational Medical Research Center for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
National Medical Research Center of Cardiology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied modulation of the expression of extracellular matrix proteins under conditions of meprin inhibition in rats with LPS-induced endotoxemia. Endotoxemia increased the expression of type I, III, IV collagens and fibronectin in the renal tissue and type III and IV collagens in the heart. Meprin inhibitor actinonin reduced expression of both meprins and genes of extracellular matrix proteins, but the intensity of this effect in the heart and kidney was different. Inhibition of meprins in endotoxemia can prevent pathological remodeling of the extracellular matrix in the heart and kidney.

Indexed as

AnimalsCollagenEndotoxemiaExtracellular Matrix ProteinsHydroxamic AcidsKidneyMetalloendopeptidasesMyocardiumRatsactinoninCollagenExtracellular Matrix ProteinsHydroxamic Acidsmeprin AMetalloendopeptidasesactinonincollagensextracellular matrixgene expressionmeprins

Identifiers

PMID33893962
OpenAlexW3153549551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.