Evidence map›Paper›PMID 33893923›Full record

ArticleJournal of neuro-oncology2021

Relationship between 7T MR-angiography features of vascular injury and cognitive decline in young brain tumor patients treated with radiation therapy.

Sivakami Avadiappan, Melanie A Morrison, Angela Jakary, Erin Felton, Schuyler Stoller, Christopher P Hess, Annette M Molinaro, Steve E Braunstein, Sabine Mueller, Janine M Lupo

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sivakami AvadiappanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, Byers Hall, 1700 4th Street, Suite 303D, Box 2532, San Francisco, CA, 94158-2330, USA.
Melanie A MorrisonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, Byers Hall, 1700 4th Street, Suite 303D, Box 2532, San Francisco, CA, 94158-2330, USA.
Angela JakaryDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, Byers Hall, 1700 4th Street, Suite 303D, Box 2532, San Francisco, CA, 94158-2330, USA.
Erin FeltonDepartment of Neurology, University of California, San Francisco, CA, USA.
Schuyler StollerDepartment of Neurology, University of California, San Francisco, CA, USA.
Christopher P HessDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, Byers Hall, 1700 4th Street, Suite 303D, Box 2532, San Francisco, CA, 94158-2330, USA.
Annette M MolinaroDepartment of Neurosurgery, University of California, San Francisco, CA, USA.
Steve E BraunsteinDepartment of Radiation Oncology, University of California, San Francisco, CA, USA.
Sabine MuellerDepartment of Neurology, University of California, San Francisco, CA, USA.
Janine M LupoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, Byers Hall, 1700 4th Street, Suite 303D, Box 2532, San Francisco, CA, 94158-2330, USA. janine.lupo@ucsf.edu.ORCID http://orcid.org/0000-0002-0051-6387

Funding

MICROBLEEDS AS A MARKER OF RADIATION-INDUCED BRAIN INJURY IN PEDIATRIC PATIENTSR01HD079568 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LUPO, JANINE MARIE · 2015 to 2019
$2.5M
National Institute of Child Health and Human Development RO1HD079568NICHD NIH HHS R01 HD079568
6 · The paper itself

Abstract

purposeAlthough radiation therapy (RT) is a common treatment for pediatric brain tumors, it is associated with detrimental long-term effects such as impaired cognition, vascular injury, and increased stroke risk. This study aimed to develop metrics that describe vascular injury and relate them to the presence of cerebral microbleeds (CMBs) and cognitive performance scores.

methodsTwenty-five young adult survivors of pediatric brain tumors treated with either whole-brain (n = 12), whole-ventricular (n = 7), or no RT (n = 6) underwent 7T MRI and neurocognitive testing. Simultaneously acquired MR angiography and susceptibility-weighted images were used to segment CMBs and vessels and quantify their radii and volume.

resultsPatients treated with whole-brain RT had significantly lower arterial volumes (p = 0.003) and a higher proportion of smaller vessels (p = 0.003) compared to the whole-ventricular RT and non-irradiated control patients. Normalized arterial volume decreased with increasing CMB count (R = - 0.66, p = 0.003), and decreasing trends were observed with time since RT and at longitudinal follow-up. Global cognition and verbal memory significantly decreased with smaller normalized arterial volume (p ≤ 0.05).

conclusionsArterial volume is reduced with increasing CMB presence and is influenced by the total brain volume exposed to radiation. This work highlights the potential use of vascular-derived metrics as non-invasive markers of treatment-induced injury and cognitive impairment in pediatric brain tumor patients.

Indexed as

Brain NeoplasmsCognitive DysfunctionVascular System InjuriesAngiographyBrainCerebral HemorrhageHumansMagnetic Resonance ImagingCerebral microbleedsLate radiation effectsMR angiographyPediatric brain tumorsSusceptibility-weighted imagingVascular injury

Identifiers

PMID33893923
PMCPMC8172069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.