Evidence map›Paper›PMID 33893877›Full record

ArticleAIDS and behavior2021

Point-of-Care Test for Assessing Tenofovir Adherence: Feasibility and Recommendations from Women in an Oral PrEP Program in Kenya and Their Healthcare Providers.

Nicholas Thuo, Madison Polay, Anna M Leddy, Kenneth Ngure, Purba Chatterhee, Monica Gandhi, K Rivet Amico

Abstract read
In one paragraph

Article in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicholas ThuoCentre for Clinical Research, Kenya Medical Research Institute, -PHRD, Thika Project, Nairobi, Kenya.
Madison PolayHealth Behavior Health Education, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Anna M LeddyDivision of Prevention Science, Department of Medicine, University of California, San Francisco, CA, USA.
Kenneth NgureCentre for Clinical Research, Kenya Medical Research Institute, -PHRD, Thika Project, Nairobi, Kenya.
Purba ChatterheeDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, CA, USA.
Monica GandhiDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, CA, USA.
K Rivet AmicoHealth Behavior Health Education, School of Public Health, University of Michigan, Ann Arbor, MI, USA. ramico@umich.edu.ORCID http://orcid.org/0000-0002-4458-6934

Funding

INTERNATIONAL TRAINING GRANT IN EPIDEMIOLOGYD43TW000007 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 1988 to 2012
$16.3M
TRAINEESHIPS IN AIDS PREVENTION STUDIEST32MH019105 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carol Suzanne Camlin, Glenn-Milo Santos · 1989 to 2026
$15.3M
Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING-PUMA)R01AI143340 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2018 to 2026
$5.6M
Women and HIV: Translation of Research into Practice-WLHIV Post-Graduate Research FellowshipD43TW009783 · FIC · UNIVERSITY OF WASHINGTON · PI Elizabeth Anne BUKUSI, CAREY FARQUHAR · 2015 to 2026
$4.1M
Urine tenofovir point-of-care test to identify patients in need of ART adherence supportR01AI152119 · NIAID · STELLENBOSCH UNIVERSITY · PI GANDHI, MONICA, ORRELL, CATHERINE · 2020 to 2024
$1.7M
FIC NIH HHS D43 TW000007FIC NIH HHS D43 TW009783NIAID NIH HHS R01 AI143340NIAID NIH HHS R01 AI152119NIMH NIH HHS R01AI143340NIMH NIH HHS T32 MH019105
6 · The paper itself

Abstract

Oral pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality when taken as recommended. Women in sub-Saharan Africa may have adherence challenges that remain undisclosed to providers. Real-time measures that identify non-adherence can allow for immediate exploration of adherence challenges, counseling and interventions. We conducted a formative qualitative study in Kenya to explore oral PrEP experiences and reactions to a point-of-care urine test (UT) identifying recent (past 4 days) non-adherence to tenofovir-based PrEP among female PrEP users (25 in-depth interviews; 4 focus groups) and health care provider (10 key informant interviews). Findings indicate that use of the UT would be highly feasible in the context of regular PrEP care, largely acceptable to clients and providers, and could improve adherence. Clients emphasized the need for transparent client-centered strategies in delivering results. This formative study informs the development of tools to implement this point-of-care UT in future interventional studies and clinical settings.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisFeasibility StudiesFemaleHealth PersonnelHumansKenyaMedication AdherencePoint-of-Care TestingTenofovirAnti-HIV AgentsTenofovirAdherenceMeasurementPrEPTDF/FTCUrine test

Identifiers

PMID33893877
PMCPMC9271229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.