SynthesisBJS open2021
Defining indocyanine green fluorescence to assess anastomotic perfusion during gastrointestinal surgery: systematic review.
Synthesis in BJS open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Indocyanine green fluorescence-guided perfusion vs. standard assessment to prevent clinical anastomotic leak after colorectal resection: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials with site-specific subgroup analysis.World journal of surgical oncology · 2025Pooled it
- Indocyanine green and height of anastomosis in colorectal surgery- a network meta-analysis.Langenbeck's archives of surgery · 2025Pooled it
- Quantitative assessment of gastric tube perfusion during Ivor Lewis esophagectomy using indocyanine-green: results from the prospective interventional trial SPY Q-ICG PAS study.Surgical endoscopy · 2026Trial
- Intraoperative spectral imaging versus ICG fluorescence for gastric conduit viability in esophagectomy.Surgical endoscopy · 2026Article
- Routine Intraoperative ICG Perfusion Assessment and Anastomotic Leak After Esophagectomy: A Before-After Cohort Study.Journal of clinical medicine · 2026Article
- Extra-Abdominal Applications of the Greater Omentum in Canine and Feline Surgery: Current Knowledge, Surgical Techniques, and Clinical Perspectives.Animals : an open access journal from MDPI · 2026Review
- Perioperative splanchnic perfusion variation around colorectal surgery using both indocyanine green spectrophotometry and fluorescence angiography.Surgical endoscopy · 2026Article
- Continuous assessment of tissue perfusion using quantitative indocyanine green fluorescence imaging during controlled hypo- and reperfusion.Surgical endoscopy · 2025Article
- Prospective analysis of factors influencing the change of the section line based on fluorescence angiography with ICG for colorectal anastomosis.Techniques in coloproctology · 2025Article
- Review
- Establishing reference curves for vital tissue perfusion using quantitative near-infrared fluorescence imaging with indocyanine green.Langenbeck's archives of surgery · 2025Article
- Local Myoelectric Sensing During Human Colonic Tissue Perfusion.Diagnostics (Basel, Switzerland) · 2024Article
- Does Indocyanine Green Utilization during Esophagectomy Prevent Anastomotic Leaks? Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Late-onset lethal complication of non-surgically managed massive gastric conduit necrosis after esophagectomy: a case report.Surgical case reports · 2024Article
- NIR-II light in clinical oncology: opportunities and challenges.Nature reviews. Clinical oncology · 2024Review
- Current applications of indocyanine green (ICG) in abdominal, gynecologic and urologic surgery: a meta-review and quality analysis with use of the AMSTAR 2 instrument.Surgical endoscopy · 2024Review
- Quantification of indocyanine green near-infrared fluorescence bowel perfusion assessment in colorectal surgery.Surgical endoscopy · 2023Article
- Real-time quantification of bowel perfusion using Laparoscopic Laser Speckle Contrast Imaging (LSCI) in a porcine model.BMC surgery · 2023Article
- Intraoperative pancreas stump perfusion assessment during pancreaticoduodenectomy: A systematic scoping review.World journal of gastrointestinal surgery · 2023Article
- Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage.Medicina (Kaunas, Lithuania) · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this systematic review was to identify all methods to quantify intraoperative fluorescence angiography (FA) of the gastrointestinal anastomosis, and to find potential thresholds to predict patient outcomes, including anastomotic leakage and necrosis.
methodsThis systematic review adhered to the PRISMA guidelines. A PubMed and Embase literature search was performed. Articles were included when FA with indocyanine green was performed to assess gastrointestinal perfusion in human or animals, and the fluorescence signal was analysed using quantitative parameters. A parameter was defined as quantitative when a diagnostic numeral threshold for patient outcomes could potentially be produced.
resultsSome 1317 articles were identified, of which 23 were included. Fourteen studies were done in patients and nine in animals. Eight studies applied FA during upper and 15 during lower gastrointestinal surgery. The quantitative parameters were divided into four categories: time to fluorescence (20 studies); contrast-to-background ratio (3); pixel intensity (2); and numeric classification score (2). The first category was subdivided into manually assessed time (7 studies) and software-derived fluorescence-time curves (13). Cut-off values were derived for manually assessed time (speed in gastric conduit wall) and derivatives of the fluorescence-time curves (Fmax, T1/2, TR and slope) to predict patient outcomes.
conclusionTime to fluorescence seems the most promising category for quantitation of FA. Future research might focus on fluorescence-time curves, as many different parameters can be derived and the fluorescence intensity can be bypassed. However, consensus on study set-up, calibration of fluorescence imaging systems, and validation of software programs is mandatory to allow future data comparison.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.