ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2021
Leptin Influence Cholelithiasis Formation by Regulating Bile Acid Metabolism.
Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Is hyperleptinemia associated with gallstone disease? A systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Pooled it
- Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017-2020.BMC gastroenterology · 2025Article
- Higher relative fat mass was associated with a higher prevalence of gallstones in US adults.BMC gastroenterology · 2025Article
- Gallstones in the Era of Metabolic Syndrome: Pathophysiology, Risk Prediction, and Management.Cureus · 2025Review
- Cardiometabolic index as a predictor of gallstone incidence in U.S. adults: insights from NHANES 2017-2020.BMC gastroenterology · 2025Article
- Relationship between high-fat diet, gut microbiota, and precocious puberty: mechanisms and implications.Frontiers in microbiology · 2025Review
- Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017-2020.BMC gastroenterology · 2024Article
- Association between lipid accumulation products and gallstones: an analysis of the National Health and Nutrition Examination Survey 2017-2020.BMC gastroenterology · 2024Article
- Relationship of triglyceride-glucose index to gallstone prevalence and age at first gallstone surgery in American adults.Scientific reports · 2024Article
- Association between triglyceride glucose index-related indices with gallstone disease among US adults.Lipids in health and disease · 2024Article
- Association between weight-adjusted-waist index and gallstones: an analysis of the National Health and Nutrition Examination Survey.BMC gastroenterology · 2024Article
- Elevated metabolic score for visceral fat was associated with increased prevalence of gallstones in American adults: a cross-sectional study.Frontiers in medicine · 2024Article
- Elevated TyG index associated with increased prevalence of gallstones in a United States cross-sectional study.Frontiers in public health · 2024Article
- AQP3-mediated activation of the AMPK/SIRT1 signaling pathway curtails gallstone formation in mice by inhibiting inflammatory injury of gallbladder mucosal epithelial cells.Molecular medicine (Cambridge, Mass.) · 2023Article
- Relationship between weight-adjusted waist circumference index and prevalence of gallstones in U.S. adults: a study based on the NHANES 2017-2020.Frontiers in endocrinology · 2023Article
- Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis.The American journal of pathology · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBile acid metabolism is a contributing factor that promotes cholelithiasis. Recent studies have suggested novel roles of leptin in the formation of gallbladder stones (GS); however, no evidence confirmed the function of leptin in the formation of primary intrahepatic bile duct stones (PIBDS) . In the current study, the liver tissues of patients with GS and PIBDS were collected to check the mRNA and protein expression levels of BSEP.
methodsL02 cells stimulated with leptin were served for the expression of OB-Rb, AMPKα2, and BSEP by quantitative-polymerase chain reaction (q-PCR), Western blot, and immunohistochemistry, respectively.
resultsThe results showed that the level of serum leptin was higher in the GS group than in the control and PIBDS groups. Compared with the control group, the expression levels of OB-Rb, p-AMPKa2, and BSEP decreased significantly in the GS and PIBDS groups. In vitro, compared with the control cells, the protein levels of OB-Rb, p-AMPKa2, and BSEP increased in the L02 cells cultured with leptin. However, these enhancements disappeared when the cells were co-cultured with leptin plus Compound C.
conclusionThe present results suggest that cholelithiasis, especially the formation of PIBDS, was connected with leptin, which could regulate bile acid metabolism through the OB-Rb/AMPKa2/BSEP signaling pathway.
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