Evidence map›Paper›PMID 33893768›Full record

Observational studyThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2021

Gut Microbiota Characteristics in Children After the Use of Proton Pump Inhibitors.

Lila Simakachorn, Pornthep Tanpowpong, Suwanee Chanprasertyothin, Supranee Thongpradit, Suporn Treepongkaruna

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07036627 (Evaluation of the Intestinal Microbiota in Pediatric Patients Treated With Proton Pump Inhibitors), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07036627 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Intestinal Microbiota in Pediatric Patients Treated With Proton Pump Inhibitors: A Prospective Longitudinal Study

TypeobservationalSponsorUniversity of BariRan2025 to 2027Enrolled100ConditionsProton Pump Inhibitors, Human Gastrointestinal Tract, Gastroesophageal Reflux DiseaseArmsstudy of microbiota
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lila SimakachornDivision of Gastroenterology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University School of Medicine, Thailand.
Pornthep TanpowpongDivision of Gastroenterology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University School of Medicine, Thailand.
Suwanee ChanprasertyothinResearch Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand.
Supranee ThongpraditResearch Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand.
Suporn TreepongkarunaDivision of Gastroenterology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University School of Medicine, Thailand.
Ramathibodi Hospital · THMahidol University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsProlonged acid suppression from proton pump inhibitor (PPI) has been shown to cause gut microbiota alteration which may increase risk of various infections in adults. We aimed to characterize gut microbiota profiles in children after a short-term use of PPI. MATERIALS AND

methodsChildren aged 1-18 years who underwent PPI therapy were included during April-December 2017. We excluded children who previously used antibiotics or acid suppressants, had a history of acute gastroenteritis or specific food avoidance one month prior to the enrolment. The stool samples before and after the PPI use were collected for gut microbiota composition. The 16S ribosomal RNA gene sequencing was performed by using Illumina MiSeq. The differences in gut microbiota profile after the use of PPI were compared to pre-PPI period.

resultsWe completed stool collection in 20 children (median age of 5.8 years and 60% were female). No significant changes in the overall number of species-level taxonomy categories or predominant bacteria phylum (Bacteroidetes) were noted. We found a trend increase in the proportion of phylum Firmicutes among children living in the metropolitan/suburban area (P=.07) and among males (P=.11). In four children with infection-related adverse effects, we noted a non-significant increase in the proportion of phylum Firmicutes after the PPI use (from 35 to 52%, P = .14).

conclusionEven the total number and predominant gut microbiota did not significantly change after a four- to eight-week course of PPI therapy; we found a trend of increased proportion of phylum Firmicutes in certain groups of children.

Indexed as

Gastrointestinal MicrobiomeProton Pump InhibitorsAdolescentChildChild, PreschoolDigestive System DiseasesFecesFemaleHumansInfantMaleProspective StudiesProton Pump Inhibitors

Identifiers

PMID33893768
PMCPMC8975470
OpenAlexW3048426325

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.