Evidence map›Paper›PMID 33893749›Full record

ArticleEnvironmental microbiology2021

Aspartate in the intestine: dual service as anaerobic electron acceptor and nitrogen source.

Tyrrell Conway

Open access · greenAbstract readComment
In one paragraph

Article in Environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Tyrrell ConwayDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma, 74078, USA.ORCID 0000-0002-0938-4149
Oklahoma State University · US

Funding

Mechanisms of Nutrient Competition in the IntestineR01GM117324 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI CONWAY, TYRRELL · 2017 to 2020
$1.4M
NIGMS NIH HHS R01 GM117324
6 · The paper itself

Abstract

Fumarate was previously known to serve as an anaerobic electron acceptor by E. coli when colonizing the mammalian intestine, but the source of that fumarate was elusive. In this issue, Unden and coworkers demonstrate that l-aspartic acid is the source of fumarate that drives anaerobic respiration by colonized E. coli (Schubert et al., 2021). Moreover, Schubert et al., establish that E. coli is able to grow anaerobically by using aspartate as a sole source of nitrogen. These groundbreaking findings indicate that a single amino acid - aspartate - supports anaerobic respiration and acquisition of nitrogen by E. coli in the intestine.

Indexed as

Aspartic AcidEscherichia coliAnaerobiosisAnimalsElectronsFumaratesIntestinesNitrogenAspartic AcidFumaratesNitrogen

Identifiers

PMID33893749
PMCPMC8544756
OpenAlexW3153374020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.