Evidence map›Paper›PMID 33893738›Full record

Trial reportBJS open2021

The effect of remote ischaemic preconditioning on postoperative cardiac and inflammatory biomarkers in pancreatic surgery: a randomized controlled trial.

L van Zeggeren, R A Visser, L M Vernooij, I M Dijkstra, M Bosma, Q Molenaar, H C van Santvoort, P G Noordzij

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BJS open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03460938 (The Effect of Remote Ischemic Preconditioning on Postoperative Myocardial Ischemia in Pancreatic Surgery), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03460938 nacompletednot on this map

The Effect of Remote Ischemic Preconditioning on Postoperative Myocardial Ischemia in Pancreatic Surgery: a Randomized Controlled Trial

TypeinterventionalSponsorSt. Antonius HospitalRan2017 to 2019Enrolled90ConditionsMyocardial Ischemia, Inflammatory ResponseArmsRemote ischemic preconditioning
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

L van ZeggerenDepartments of Anaesthesiology, Intensive Care and Pain Medicine and Clinical Chemistry.
R A VisserDepartments of Anaesthesiology, Intensive Care and Pain Medicine and Clinical Chemistry.
L M VernooijDepartments of Anaesthesiology, Intensive Care and Pain Medicine and Clinical Chemistry.
I M DijkstraSt. Antonius Hospital, Nieuwegein, the Netherlands.
M BosmaSt. Antonius Hospital, Nieuwegein, the Netherlands.
Q MolenaarRegional Academic Cancer Centre Utrecht, Department of Hepato-Pancreato-Biliary Surgery, St. Antonius Hospital Nieuwegein & University Medical Centre Utrecht, the Netherlands.
H C van SantvoortRegional Academic Cancer Centre Utrecht, Department of Hepato-Pancreato-Biliary Surgery, St. Antonius Hospital Nieuwegein & University Medical Centre Utrecht, the Netherlands.
P G NoordzijDepartments of Anaesthesiology, Intensive Care and Pain Medicine and Clinical Chemistry.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac and inflammatory biomarkers have been associated with adverse outcome after major abdominal surgery. This study investigated the effect of remote ischaemic preconditioning (RIPC) on perioperative concentrations of high-sensitive cardiac troponin (hs-cTn) T and interleukin (IL) 6.

methodsAdult patients scheduled for elective pancreatic surgery between March 2017 and February 2019 were randomized to either three cycles of upper-limb ischaemia and reperfusion (each 5 min) or a sham procedure before surgery. The primary endpoint was the maximum postoperative hs-cTnT concentration within 48 h after surgery. Secondary endpoints were postoperative myocardial injury (PMI), defined as an absolute increase of hs-cTnT of at least 14 ng/l above baseline concentration, maximum concentration of IL-6 within 48 h after surgery and postoperative complications within 30 days of surgery.

resultsOf 99 eligible patients, 46 underwent RIPC and 46 a sham procedure. RIPC did not reduce the maximum hs-cTnT concentration after surgery (12.6 ng/l RIPC, 16.6 ng/l controls, P = 0.225), nor did it lessen the incidence of PMI (15/45 RIPC, 18/45 controls, P = 0.375). The maximum postoperative IL-6 concentration was 265 pg/ml after RIPC versus 385 pg/ml in controls (P = 0.108). Postoperative complications occurred in 23 RIPC and 24 control patients respectively.

conclusionsRemote ischaemic preconditioning did not reduce the maximum postoperative hs-cTnT concentration. Postoperative myocardial injury, IL-6 concentrations and postoperative complications were similar between RIPC patients and controls.

trial registrationClinicaltrials.gov identifier NCT03460938.

Indexed as

AgedBiomarkersDouble-Blind MethodFemaleHumansInterleukin-6Ischemic PreconditioningLinear ModelsMaleMyocardial IschemiaNetherlandsPancreaticoduodenectomyPostoperative ComplicationsTroponin TBiomarkersInterleukin-6Troponin T

Identifiers

PMID33893738
PMCPMC8065964

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.