Evidence map›Paper›PMID 33893737›Full record

Observational studyBJS open2021

Early abnormal fibrinolysis and mortality in patients with thermal injury: a prospective cohort study.

A E Pusateri, T D Le, J W Keyloun, L T Moffatt, T Orfeo, K E Brummel-Ziedins, M M McLawhorn, R A Callcut, J W Shupp, SYSCOT Study Group

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BJS open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pathophysiology of Severe Burn Injuries: New Therapeutic Opportunities From a Systems Perspective.Journal of burn care & research : official publication of the American Burn Association · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. [Paying more attention to burn induced coagulopathy].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023
    Article
  7. Review
  8. Inhalation Injury Is Associated With Endotheliopathy and Abnormal Fibrinolytic Phenotypes in Burn Patients: A Cohort Study.Journal of burn care & research : official publication of the American Burn Association · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

A E PusateriU.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas, USA.
T D LeU.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas, USA.
J W KeylounThe Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA.
L T MoffattFirefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC, USA.
T OrfeoDepartment of Biochemistry, College of Medicine, University of Vermont, Colchester, Vermont, USA.
K E Brummel-ZiedinsFirefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC, USA.
M M McLawhornFirefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC, USA.
R A CallcutDepartment of Surgery, University of California Davis School of Medicine, Sacramento, California, USA.
J W ShuppThe Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA.
SYSCOT Study Group
MedStar Health · USMedStar Washington Hospital Center · USUnited States Army Institute of Surgical Research · USGeorgetown University · USUniversity of California, Davis · USUniversity of Vermont · US

Funding

R01 Administrative Supplement for AI Prediction of Trauma Resuscitation ResponsivenessR01HL149670 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALLCUT, RACHAEL A · 2020 to 2024
$4.6M
NHLBI NIH HHS R01 HL149670
6 · The paper itself

Abstract

introductionAbnormal fibrinolysis early after injury has been associated with increased mortality in trauma patients, but no studies have addressed patients with burn injury. This prospective cohort study aimed to characterize fibrinolytic phenotypes in burn patients and to see if they were associated with mortality.

methodsPatients presenting to a regional burn centre within 4 h of thermal injury were included. Blood was collected for sequential viscoelastic measurements using thromboelastography (RapidTEG™) over 12 h. The percentage decrease in clot strength 30 min after the time of maximal clot strength (LY30) was used to categorize patients into hypofibrinolytic/fibrinolytic shutdown (SD), physiological (PHYS) and hyperfibrinolytic (HF) phenotypes. Injury characteristics, demographics and outcomes were compared.

resultsOf 115 included patients, just over two thirds were male. Overall median age was 40 (i.q.r. 28-57) years and median total body surface area (TBSA) burn was 13 (i.q.r. 6-30) per cent. Some 42 (36.5 per cent) patients had severe burns affecting over 20 per cent TBSA. Overall mortality was 18.3 per cent. At admission 60.0 per cent were PHYS, 30.4 per cent were SD and 9.6 per cent HF. HF was associated with increased risk of mortality on admission (odds ratio 12.61 (95 per cent c.i. 1.12 to 142.57); P = 0.041) but not later during the admission when its incidence also decreased. Admission SD was not associated with mortality, but incidence increased and by 4 h and beyond, SD was associated with increased mortality, compared with PHYS (odds ratio 8.27 (95 per cent c.i. 1.16 to 58.95); P = 0.034). DISCUSSION: Early abnormal fibrinolytic function is associated with mortality in burn patients.

Indexed as

AdultBlood Coagulation DisordersBody Surface AreaBurnsFemaleFibrinolysisHumansIncidenceLogistic ModelsMaleMiddle AgedProspective StudiesThrombelastography

Identifiers

PMID33893737
PMCPMC8065965
OpenAlexW3155521241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.