Evidence map›Paper›PMID 33893721›Full record

Trial reportObesity (Silver Spring, Md.)2021

Adipocyte Proteins and Storage of Endogenous Fatty Acids in Visceral and Subcutaneous Adipose Tissue in Severe Obesity.

Kelli A Lytle, Nikki C Bush, Jessica M Triay, Todd A Kellogg, Michael L Kendrick, James M Swain, Nicola W Gathaiya, Kazanna C Hames, Michael D Jensen

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kelli A LytleEndocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA.
Nikki C BushEndocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA.
Jessica M TriayEndocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA.
Todd A KelloggDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Michael L KendrickDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
James M SwainDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Nicola W GathaiyaEndocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA.
Kazanna C HamesEndocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA.
Michael D JensenEndocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-5589-8389
Mayo Clinic in Florida · USMayo Clinic · US

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Obesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BERNLOHR, DAVID A · 1995 to 2015
$17.0M
REGIONAL FATTY ACID METABOLISM IN HUMANSR01DK045343 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1992 to 2026
$12.9M
DIABETES AND METABOLISMT32DK007352 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1986 to 2026
$9.4M
FFA METABOLISM IN DIFFERENT TYPES OF HUMAN OBESITYR01DK040484 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1993 to 2026
$8.2M
Free Fatty Acid Metabolism in Different Types of Human ObesityR37DK040484 · NIDDK · MAYO CLINIC ROCHESTER · PI JENSEN, MICHAEL D. · 2003 to 2012
$4.1M
NCATS NIH HHS UL1 TR000135NCRR NIH HHS UL1 RR024150NIDDK NIH HHS P30 DK050456NIDDK NIH HHS R01 DK040484NIDDK NIH HHS R01 DK045343NIDDK NIH HHS R37 DK040484NIDDK NIH HHS T32 DK007352
6 · The paper itself

Abstract

objectiveThis study tested whether substrate concentrations or fatty acid storage proteins predict storage of endogenous lipids in visceral adipose tissue (VAT) and upper body subcutaneous adipose tissue (UBSQ) fat.

methodsThe day prior to surgery, 25 patients undergoing bariatric procedures received an infusion of autologous [1-

resultsStorage of VLDL-TG and FFA-palmitate in UBSQ and VAT was not different. Plasma palmitate concentrations correlated with palmitate storage rates in UBSQ and VAT (r = 0.46, P = 0.02 and r = 0.46, P = 0.02, respectively). In VAT, VLDL-TG storage was correlated with VLDL concentrations (r = 0.53, P < 0.009) and LPL (r = 0.42, P < 0.05). In UBSQ, VLDL-TG storage was correlated with LPL (r = 0.42, P < 0.05). CD36, acyl-CoA synthetase, glycerol-3-phosphate acyltransferase, and diacylglycerol acetyl-transferase were not correlated with VLDL-TG or palmitate storage.

conclusionsAdipose storage of VLDL-TG is predicted by VLDL-TG concentrations and LPL; FFA concentrations predict direct adipose tissue FFA storage rates.

Indexed as

AdipocytesAdipose TissueAdolescentAdultBariatric SurgeryFatty AcidsFatty Acids, NonesterifiedFemaleHumansIntra-Abdominal FatLipoproteins, VLDLMaleMiddle AgedObesity, MorbidSubcutaneous FatTriglyceridesFatty AcidsFatty Acids, NonesterifiedLipoproteins, VLDLTriglyceridesvery low density lipoprotein triglyceride

Identifiers

PMID33893721
PMCPMC8154683
OpenAlexW3155776186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.