Evidence map›Paper›PMID 33893607›Full record

ArticleActa parasitologica2021

Mice Intragastric Infected with Insect and Blood Trypomastigotes of Trypanosoma cruzi IV: Differences and Similarities on the Evolution Profile and Response to Etiological Treatment.

Miyoko Massago, Gerson Zanusso Junior, Elaine Schultz Dworak, Elisama Loubak da Silva, Alexandre Tadachi Morey, Mônica Lúcia Gomes, Max Jean de Ornelas Toledo

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Article in Acta parasitologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Miyoko MassagoInterdisciplinary Dynamic Museum, State University of Maringa, Av. Colombo 5790, Bloco I-90, Zona 7, Maringa, Paraná, 87020-900, Brazil. mi_massago@hotmail.com.ORCID http://orcid.org/0000-0001-6805-5399
Gerson Zanusso JuniorBlood Center at State University of Maringa, Maringa, Paraná, Brazil.
Elaine Schultz DworakPost-Graduate Program of Health Sciences, Health Sciences Center at State University of Maringa, Maringa, Paraná, Brazil.ORCID http://orcid.org/0000-0002-4710-8778
Elisama Loubak da SilvaPost-Graduate Program of Health Sciences, Health Sciences Center at State University of Maringa, Maringa, Paraná, Brazil.
Alexandre Tadachi MoreyFederal Institute of Education, Science and Technology of Rio Grande do Sul, Canoas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0001-9975-4627
Mônica Lúcia GomesPost-Graduate Program of Health Sciences, Health Sciences Center at State University of Maringa, Maringa, Paraná, Brazil.ORCID http://orcid.org/0000-0001-5701-5375
Max Jean de Ornelas ToledoPost-Graduate Program of Biological Sciences, Biological Sciences Center at State University of Maringa, Maringa, Paraná, Brazil.ORCID http://orcid.org/0000-0001-6314-8668
Universidade Estadual de Maringá · BRInstituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 307539/2013Fundação Araucária 251/2014
6 · The paper itself

Abstract

purposeOur goal was to analyze the outcome of infection and response to benznidazole (BZ) treatment in mice intragastrically inoculated with trypomastigotes forms of Trypanosoma cruzi from different origins.

methodsTwenty-four Swiss mice were divided in two groups and inoculated, by gavage, with 1 × 10

resultsAnimals inoculated with BT showed lower pre-patent period and early day of the maximum parasitemia, as well as a higher maximum peak of parasitemia than the IT animals. However, both, BT and IT animals, did not respond to BZ treatment (0.0% of cure).

conclusionWe conclude that the infective form influences in the outcome of infection, but not the response to the etiological treatment in mice intragastrically infected with the T. cruzi IV strain studied.

Indexed as

Chagas DiseaseTrypanosoma cruziAnimalsInsectaMiceParasitemiaEtiological treatmentEvolutionIntragastric infectionMiceOrigin of trypomastigotes

Identifiers

PMID33893607
OpenAlexW3152590661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.