Evidence map›Paper›PMID 33893558›Full record

ArticleBiomechanics and modeling in mechanobiology2021

A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes.

Q Peng, F J Vermolen, D Weihs

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Q PengDelft Institute of Applied Mathematics, Delft University of Technology, Mekelweg 4, 2628 CD, Delft, The Netherlands. Q.Peng-1@tudelft.nl.ORCID http://orcid.org/0000-0002-7077-0727
F J VermolenDelft Institute of Applied Mathematics, Delft University of Technology, Mekelweg 4, 2628 CD, Delft, The Netherlands.
D WeihsFaculty of Biomedical Engineering, Technion-Israel Institute of Technology, 3200003, Haifa, Israel.
Hasselt University · BETechnion – Israel Institute of Technology · IL

Funding

Israeli Ministry of Science and Technology (MOST) Medical Devices Program 3-17427
6 · The paper itself

Abstract

The phenomenological model for cell shape deformation and cell migration Chen (BMM 17:1429-1450, 2018), Vermolen and Gefen (BMM 12:301-323, 2012), is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell differentiation. Plastic deformations of the extracellular matrix are modelled using morphoelasticity theory. The resulting partial differential differential equations are solved by the use of the finite element method. The paper treats various biological scenarios that entail cell migration and cell shape evolution. The experimental observations in Mak et al. (LC 13:340-348, 2013), where transmigration of cancer cells through narrow apertures is studied, are reproduced using a Monte Carlo framework.

Indexed as

Cell DifferentiationCell MovementBiomechanical PhenomenaBiophysicsCell MembraneCell ShapeComputer SimulationExtracellular MatrixFinite Element AnalysisHumansModels, BiologicalModels, TheoreticalMonte Carlo MethodNeoplasm MetastasisNeoplasmsWound HealingAgent-based modellingCell geometryCell migrationCellular traction forcesFinite-element method

Identifiers

PMID33893558
PMCPMC8298374
OpenAlexW3113164476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.