ArticleCommunications biology2021
Ecological niche adaptation of Salmonella Typhimurium U288 is associated with altered pathogenicity and reduced zoonotic potential.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Nationwide trends and features of human salmonellosis outbreaks in China.Emerging microbes & infections · 2024Pooled it
- Global transmission dynamics of antibiotic resistance genes: Foodborne pathways as the critical link to humans.One health (Amsterdam, Netherlands) · 2026Article
- Building resilient food safety systems through a One Health approach to prepare for the next pandemic.NPJ science of food · 2026Review
- Host adaptation inApplied and environmental microbiology · 2026Review
- GWAS and Machine Learning Screening of Genomic Determinants Underlying Host Adaptation in Swine and ChickenMicroorganisms · 2026Article
- Prophage diversity in poultry-associatedFrontiers in microbiology · 2026Article
- Machine learning based on pangenome-wide association studies reveals the impact of host source on the zoonotic potential of closely related bacterial pathogens.Communications biology · 2025Article
- Genome-wide association mapping dissects the selective breeding of determinacy and photoperiod sensitivity in common bean (Phaseolus vulgaris L.).G3 (Bethesda, Md.) · 2025Article
- Reversible excision of the wzy locus in Salmonella Typhimurium may aid recovery following phage predation.PLoS genetics · 2025Article
- Temporal changes in fecal swine microbiome primarily reflectFrontiers in veterinary science · 2025Article
- Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China.Infection and drug resistance · 2025Article
- ICEmST contributes to colonization of Salmonella in the intestine of piglets.Scientific reports · 2024Article
- Multidrug resistance plasmids underlie clonal expansions and international spread of Salmonella enterica serotype 1,4,[5],12:i:- ST34 in Southeast Asia.Communications biology · 2023Article
- Whole-Genome Subtyping Reveals Population Structure and Host Adaptation of Salmonella Typhimurium from Wild Birds.Journal of clinical microbiology · 2023Article
- Phytochemicals: potential alternative strategy to fightFrontiers in veterinary science · 2023Review
- Increased phage resistance through lysogenic conversion accompanying emergence of monophasicMicrobial genomics · 2022Article
- Genomic Characterization ofMicroorganisms · 2022Article
- Comparative Genomic Analysis of Salmonella enterica Serovar Typhimurium Isolates from Passerines Reveals Two Lineages Circulating in Europe, New Zealand, and the United States.Applied and environmental microbiology · 2022Article
- Evidence for common ancestry and microevolution of passerine-adaptedMicrobial genomics · 2022Article
- Whole-genome epidemiology links phage-mediated acquisition of a virulence gene to the clonal expansion of a pandemicMicrobial genomics · 2020Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
The emergence of new bacterial pathogens is a continuing challenge for agriculture and food safety. Salmonella Typhimurium is a major cause of foodborne illness worldwide, with pigs a major zoonotic reservoir. Two phylogenetically distinct variants, U288 and ST34, emerged in UK pigs around the same time but present different risk to food safety. Here we show using genomic epidemiology that ST34 accounts for over half of all S. Typhimurium infections in people while U288 less than 2%. That the U288 clade evolved in the recent past by acquiring AMR genes, indels in the virulence plasmid pU288-1, and accumulation of loss-of-function polymorphisms in coding sequences. U288 replicates more slowly and is more sensitive to desiccation than ST34 isolates and exhibited distinct pathogenicity in the murine model of colitis and in pigs. U288 infection was more disseminated in the lymph nodes while ST34 were recovered in greater numbers in the intestinal contents. These data are consistent with the evolution of S. Typhimurium U288 adaptation to pigs that may determine their reduced zoonotic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.