ArticleScientific reports2021
The influence of axial myopia on optic disc characteristics of glaucoma eyes.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deep learning and optical coherence tomography in glaucoma: Bridging the diagnostic gap on structural imaging.Frontiers in ophthalmology · 2022Pooled it
- Ocular Blood Flow in Eyes with Myopia and Glaucoma: From Pathophysiology to Clinical Implications.Journal of clinical medicine · 2026Review
- Diagnostic Performance of Artificial Intelligence Corrected OCT Measurements in Highly Myopic Eyes with Glaucoma.Journal of clinical medicine · 2026Article
- Long-Term Reproducibility of OCT Angiography Parameters in Patients with High Myopia.Ophthalmology science · 2026Article
- Myopic and Glaucomatous Optic Neuropathy in Highly Myopic Eyes: A Practical Framework for Diagnosis, Monitoring, and Management.Journal of clinical medicine · 2026Review
- Interaction of Myopic Optic Neuropathy (MON) and Glaucomatous Optic Neuropathy (GON): Pathophysiology and Clinical Implications.Journal of clinical medicine · 2026Review
- Comparison of the diagnostic performance of two spectral-domain OCT machines in detecting glaucoma in high and non-high axial myopia eyes.International ophthalmology · 2025Article
- Peripapillary intrachoroidal cavitation in myopic eyes with open-angle glaucoma: association with myopic fundus changes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Detecting Glaucoma in Highly Myopic Eyes From Fundus Photographs Using Deep Convolutional Neural Networks.Clinical & experimental ophthalmology · 2025Article
- The role of peripapillary vessel density and retinal nerve fiber layer thickness in diagnosing and monitoring myopic glaucoma.Frontiers in medicine · 2025Article
- Measurement of the Tilt Angle of the Optic Disc Using Spectral-Domain Optical Coherence Tomography and Related Factors in Myopia.Translational vision science & technology · 2024Article
- Wide-Field Optical Coherence Tomography Imaging Improves Rate of Change Detection in Progressing Glaucomatous Eyes Compared With Standard-Field Imaging.Investigative ophthalmology & visual science · 2024Article
- OCT Optic Nerve Head Morphology in Myopia IV: Neural Canal Scleral Flange Remodeling in Highly Myopic Eyes.American journal of ophthalmology · 2024Article
- Quantitative Assessment of Fundus Tessellated Density in Highly Myopic Glaucoma Using Deep Learning.Translational vision science & technology · 2024Article
- Morphological differences of the neuroretinal rim between temporally tilted and non-tilted optic discs in healthy eyes.Scientific reports · 2024Article
- Temporal Optic Disc Microvasculature Dropout in Glaucoma.Investigative ophthalmology & visual science · 2023Article
- OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia-An American Ophthalmological Society Thesis.American journal of ophthalmology · 2023Article
- Deep Optic Nerve Head Structures Associated With Increasing Axial Length in Healthy Myopic Eyes of Moderate Axial Length.American journal of ophthalmology · 2023Observational
- Structure Function Relationships of Vessel Density and Retinal Nerve Fiber Layer Thickness in Early Glaucomatous Eyes With High Myopia.Investigative ophthalmology & visual science · 2023Article
- A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia.Frontiers in genetics · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
This study characterizes differences in glaucomatous eyes with and without high axial myopia using custom automated analysis of OCT images. 452 eyes of 277 glaucoma patients were stratified into non (n = 145 eyes), mild (n = 214 eyes), and high axial myopia (axial length (AL) > 26 mm, n = 93 eyes). Optic disc ovality index, tilt and rotation angle of Bruch´s membrane opening (BMO) and peripapillary choroidal thickness (PCT) were calculated using automated and deep learning strategies. High myopic optic discs were more oval and had larger BMO tilt than mild and non-myopic discs (both p < 0.001). Mean PCT was thinnest in high myopic eyes followed by mild and non-myopic eyes (p < 0.001). BMO rotation angle, global retinal nerve fiber layer (RNFL) thickness and BMO-minimum rim width (MRW) were similar among groups. Temporal RNFL was thicker and supranasal BMO-MRW was thinner in high myopic eyes. BMO tilt and PCT showed moderate and temporal RNFL and nasal BMO-MRW showed weak but significant associations with AL in multivariable analyses (all p < 0.05). Large BMO tilt angle and thin PCT are characteristics of highly myopic discs and were not associated with severity of glaucoma. Caution should be exercised when using sectoral BMO-MRW and RNFL thickness for glaucoma management decisions in myopic eyes.
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Registered trials
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