Evidence map›Paper›PMID 33893308›Full record

ArticleNature communications2021

Convergent synthesis of diversified reversible network leads to liquid metal-containing conductive hydrogel adhesives.

Yong Xu, Rebecca Rothe, Dagmar Voigt, Sandra Hauser, Meiying Cui, Takuya Miyagawa, Michelle Patino Gaillez, Thomas Kurth, Martin Bornhäuser, Jens Pietzsch and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Conductive Hydrogels for Exogenous Sensing and Cell Fate Control.Advanced materials (Deerfield Beach, Fla.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yong XuTechnische Universität Dresden, B CUBE Center for Molecular Bioengineering, Dresden, Germany.
Rebecca RotheHelmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research Department of Radiopharmaceutical and Chemical Biology, Dresden, Germany.
Dagmar VoigtTechnische Universität Dresden, Institute for Botany, Faculty of Biology, Dresden, Germany.ORCID http://orcid.org/0000-0003-2772-8504
Sandra HauserHelmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research Department of Radiopharmaceutical and Chemical Biology, Dresden, Germany.
Meiying CuiTechnische Universität Dresden, B CUBE Center for Molecular Bioengineering, Dresden, Germany.
Takuya MiyagawaTechnische Universität Dresden, B CUBE Center for Molecular Bioengineering, Dresden, Germany.
Michelle Patino GaillezTechnische Universität Dresden, B CUBE Center for Molecular Bioengineering, Dresden, Germany.ORCID http://orcid.org/0000-0002-4930-764X
Thomas KurthTechnische Universität Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Technology Platform, EM Facilty, Dresden, Germany.ORCID http://orcid.org/0000-0001-5624-1717
Martin BornhäuserCenter for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.
Jens PietzschHelmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research Department of Radiopharmaceutical and Chemical Biology, Dresden, Germany. j.pietzsch@hzdr.de.ORCID http://orcid.org/0000-0002-1610-1493
Yixin ZhangTechnische Universität Dresden, B CUBE Center for Molecular Bioengineering, Dresden, Germany. yixin.zhang1@tu-dresden.de.ORCID http://orcid.org/0000-0002-6669-4995

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many features of extracellular matrices, e.g., self-healing, adhesiveness, viscoelasticity, and conductivity, are associated with the intricate networks composed of many different covalent and non-covalent chemical bonds. Whereas a reductionism approach would have the limitation to fully recapitulate various biological properties with simple chemical structures, mimicking such sophisticated networks by incorporating many different functional groups in a macromolecular system is synthetically challenging. Herein, we propose a strategy of convergent synthesis of complex polymer networks to produce biomimetic electroconductive liquid metal hydrogels. Four precursors could be individually synthesized in one to two reaction steps and characterized, then assembled to form hydrogel adhesives. The convergent synthesis allows us to combine materials of different natures to generate matrices with high adhesive strength, enhanced electroconductivity, good cytocompatibility in vitro and high biocompatibility in vivo. The reversible networks exhibit self-healing and shear-thinning properties, thus allowing for 3D printing and minimally invasive injection for in vivo experiments.

Indexed as

Electric ConductivityAdhesivesAnimalsAnti-Bacterial AgentsBacillus subtilisBiocompatible MaterialsCell LineCell ProliferationEscherichia coliHydrogelsMetalsMiceMicroscopy, ElectronMyoblastsPolymersAdhesivesAnti-Bacterial AgentsBiocompatible MaterialsHydrogelsMetalsPolymers

Identifiers

PMID33893308
PMCPMC8065207

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.