ArticleNature communications2021
Thalamocortical excitability modulation guides human perception under uncertainty.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aging-related changes in cognitive flexibility: fMRI meta-analysis.Behavioral and brain functions : BBF · 2025Pooled it
- Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Trial
- Thalamic modulation of cortical linearity across arousal states.Science advances · 2026Article
- Distinct neural oscillations predict individual differences in feedback-guided cognitive flexibility.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia.Nature neuroscience · 2026Article
- Brain-computer interface-based neurofeedback training enables transferable control of cortical state switching in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Joint effect of uncertainty-of-outcome and calorie content on food preference.Scientific reports · 2026Article
- Neurovascular Signaling at the Gliovascular Interface: From Flow Regulation to Cognitive Energy Coupling.International journal of molecular sciences · 2025Review
- The aperiodic and periodic activities of EEG dynamically relate with cognitive performance in schizophrenia.Schizophrenia research. Cognition · 2025Review
- Thalamic regulation of reinforcement learning strategies across prefrontal-striatal networks.Nature communications · 2025Article
- Article
- Neural variability in the default mode network compresses with increasing belief precision during Bayesian inference.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Unlocking deep relaxation: the power of rhythmic breathing on brain rhythms.Npj mental health research · 2025Article
- Pumping up your predictive power for cognitive state detection with the proper GAINS.NeuroImage · 2025Article
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- Light, Sound, and Melatonin: Investigating Multisensory Pathways for Visual Restoration.Medicina (Kaunas, Lithuania) · 2025Review
- Using Electroencephalography to Advance Mindfulness Science: A Survey of Emerging Methods and Approaches.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility.Nature communications · 2025Article
- Antifragile control systems in neuronal processing: a sensorimotor perspective.Biological cybernetics · 2025Review
- Thalamocortical interactions reflecting the intensity of flicker light-induced visual hallucinatory phenomena.Network neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge about the relevance of environmental features can guide stimulus processing. However, it remains unclear how processing is adjusted when feature relevance is uncertain. We hypothesized that (a) heightened uncertainty would shift cortical networks from a rhythmic, selective processing-oriented state toward an asynchronous ("excited") state that boosts sensitivity to all stimulus features, and that (b) the thalamus provides a subcortical nexus for such uncertainty-related shifts. Here, we had young adults attend to varying numbers of task-relevant features during EEG and fMRI acquisition to test these hypotheses. Behavioral modeling and electrophysiological signatures revealed that greater uncertainty lowered the rate of evidence accumulation for individual stimulus features, shifted the cortex from a rhythmic to an asynchronous/excited regime, and heightened neuromodulatory arousal. Crucially, this unified constellation of within-person effects was dominantly reflected in the uncertainty-driven upregulation of thalamic activity. We argue that neuromodulatory processes involving the thalamus play a central role in how the brain modulates neural excitability in the face of momentary uncertainty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.