Evidence map›Paper›PMID 33893247›Full record

Observational studyAging2021

Genetic landscape of breast cancer and mutation tracking with circulating tumor DNA in Chinese women.

Yinghao Wang, Lizhi Lin, Linhong Li, Jialiang Wen, Yili Chi, Rutian Hao, Xuanxuan Dai, Yizuo Chen, Duping Huang, Yili Zhou and 12 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 1 country.

Yinghao WangDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Lizhi LinDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Linhong LiOmigen, Inc., Hangzhou 310000, P.R. China.
Jialiang WenDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Yili ChiDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Rutian HaoDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Xuanxuan DaiDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Yizuo ChenDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Duping HuangDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Yili ZhouDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Jie YouDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Zhiqiang YeDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Hao ChenDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Lingli JinDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Danxiang ChenDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Fan YangDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Erjie XiaDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Xueyan MaOmigen, Inc., Hangzhou 310000, P.R. China.
Fengyu GuoOmigen, Inc., Hangzhou 310000, P.R. China.
Yunguang TongOmigen, Inc., Hangzhou 310000, P.R. China.
Min ZhengDepartment of Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Ouchen WangDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China.
Wenzhou Medical University · CNFirst Affiliated Hospital of Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considerable efforts have been devoted to exploring the breast cancer mutational landscape to understand its genetic complexity. However, no studies have yet comprehensively elucidated the molecular characterization of breast tumors in Chinese women. This study aimed to determine the potential clinical utility of peripheral blood assessment for circulating tumor-derived DNA (ctDNA) and comprehensively characterize the female Chinese population's genetic mutational spectrum. We used Omi-Seq to create cancer profiles of 273 patients enrolled at The First Affiliated Hospital of Wenzhou Medical University. The gene landscape results indicate

Indexed as

Asian PeopleBiomarkers, TumorBreastBreast NeoplasmsChinaCirculating Tumor DNAClass I Phosphatidylinositol 3-KinasesDNA Copy Number VariationsDNA Mutational AnalysisErb-b2 Receptor Tyrosine KinasesFemaleFollow-Up StudiesHumansLiquid BiopsyMastectomyMiddle AgedBiomarkers, TumorCirculating Tumor DNAClass I Phosphatidylinositol 3-KinasesERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesPIK3CA protein, humanTP53 protein, humanTumor Suppressor Protein p53breast cancerChinese womencirculating tumor DNAdigital molecular identifiermutation landscape

Identifiers

PMID33893247
PMCPMC8109076
OpenAlexW3155880520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.