Evidence map›Paper›PMID 33893168›Full record

ArticleeNeuro

Hyperexcitability and Loss of Feedforward Inhibition Contribute to Aberrant Plasticity in the

Matthew N Svalina, E Mae Guthman, Christian A Cea-Del Rio, J Keenan Kushner, Serapio M Baca, Diego Restrepo, Molly M Huntsman

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. mTOR-Dependent Spine Dynamics in Autism.Frontiers in molecular neuroscience · 2022
    Review
  7. Review
  8. Hyperexcitability and Homeostasis in Fragile X Syndrome.Frontiers in molecular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Matthew N SvalinaNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0001-9919-9053
E Mae GuthmanNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Christian A Cea-Del RioDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
J Keenan KushnerNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Serapio M BacaDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Diego RestrepoNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Molly M HuntsmanNeuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045 molly.huntsman@CUAnschutz.edu.
University of Colorado Anschutz Medical Campus · USUniversidad de Santiago de Chile · CL

Funding

PERIPHERAL MECHANISMS OF OLFACTORY RECEPTIONR01DC000566 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI RESTREPO, DIEGO · 1989 to 2022
$9.9M
Neuroscience Training GrantT32NS099042 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Nidia Calero, GIDON S FELSEN · 2016 to 2026
$2.1M
Defining Plasticity and Homeostasis in Fragile X SyndromeR56MH127213 · NIMH · UNIVERSITY OF COLORADO DENVER · PI HUNTSMAN, MOLLY-MAUREEN, RESTREPO, DIEGO · 2021 to 2021
$439k
NIDCD NIH HHS R01 DC000566NIMH NIH HHS R56 MH127213NINDS NIH HHS T32 NS099042
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is a neurodevelopmental disorder (NDD) characterized by intellectual disability, autism spectrum disorders (ASDs), and anxiety disorders. The disruption in the function of the

Indexed as

Fragile X Messenger Ribonucleoprotein 1Fragile X SyndromeAmygdalaAnimalsDisease Models, AnimalMiceMice, KnockoutSynapsesSynaptic TransmissionFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1E/I balancefeed-forward inhibitionfragile X syndromelateral amygdalasynaptic plasticity

Identifiers

PMID33893168
PMCPMC8121259
OpenAlexW3156935957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.