Evidence map›Paper›PMID 33893166›Full record

ArticleeNeuro

Environmental Enrichment Sharpens Sensory Acuity by Enhancing Information Coding in Barrel Cortex and Premotor Cortex.

He J V Zheng, Jesse P Meagher, Duo Xu, Yogi A Patel, Daniel H O'Connor, Hyung-Bae Kwon

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Merkel cell mechanotransduction facilitates adult neurogenesis and cognition in an enriched environment.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

He J V ZhengMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
Jesse P MeagherMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
Duo XuDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Yogi A PatelDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332.
Daniel H O'ConnorDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-9193-6714
Hyung-Bae KwonMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458 hkwon29@jhmi.edu.ORCID 0000-0001-5683-3720
Johns Hopkins University · USMax Planck Florida Institute for Neuroscience · USGeorgia Institute of Technology · US

Funding

Cracking the neuromodulation code at single cell resolutionDP1MH119428 · NIMH · MAX PLANCK FLORIDA CORPORATION · PI KWON, HYUNGBAE · 2018 to 2022
$5.9M
Long-term plasticity expressed in layer 2/3 cortical microcircuitsR01MH107460 · NIMH · MAX PLANCK FLORIDA CORPORATION · PI KWON, HYUNGBAE · 2015 to 2019
$2.3M
NIMH NIH HHS DP1 MH119428NIMH NIH HHS R01 MH107460
6 · The paper itself

Abstract

Environmental enrichment (EE) is beneficial to sensory functions. Thus, elucidating the neural mechanism underlying improvement of sensory stimulus discrimination is important for developing therapeutic strategies. We aim to advance the understanding of such neural mechanism. We found that tactile enrichment improved tactile stimulus feature discrimination. The neural correlate of such improvement was revealed by analyzing single-cell information coding in both the primary somatosensory cortex and the premotor cortex of awake behaving animals. Our results show that EE enhances the decision-information coding capacity of cells that are tuned to adjacent whiskers, and of premotor cortical cells.

Indexed as

Motor CortexAnimalsSomatosensory CortexTouchVibrissaeWakefulnessenriched environmentpremotor cortexsomatosensory cortextuning heterogeneitytwo-photon imagingwhisker discrimination task

Identifiers

PMID33893166
PMCPMC8143018
OpenAlexW3152747785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.