Evidence map›Paper›PMID 33893140›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar,

Andrew A Walker, Samuel D Robinson, Jean-Paul V Paluzzi, David J Merritt, Samantha A Nixon, Christina I Schroeder, Jiayi Jin, Mohaddeseh Hedayati Goudarzi, Andrew C Kotze, Zoltan Dekan and 6 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
10.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Toxins in disguise: Neuropeptide mimicry across animal venoms.General and comparative endocrinology · 2026
    Review
  3. Genome of venomous caterpillarProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. Review
  11. Convergent evolution of toxin resistance in animals.Biological reviews of the Cambridge Philosophical Society · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Andrew A WalkerInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia; a.walker@imb.uq.edu.au glenn.king@imb.uq.edu.au.ORCID 0000-0003-1296-6593
Samuel D RobinsonInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.ORCID 0000-0002-3518-0377
Jean-Paul V PaluzziDepartment of Biology, York University, Toronto, ON M3J 1P3, Canada.ORCID 0000-0002-7761-0590
David J MerrittSchool of Biological Sciences, The University of Queensland, St. Lucia, QLD, 4072, Australia.ORCID 0000-0002-8573-7508
Samantha A NixonInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.ORCID 0000-0003-3157-4114
Christina I SchroederInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.ORCID 0000-0002-6737-6374
Jiayi JinInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Mohaddeseh Hedayati GoudarziInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Andrew C KotzeCSIRO Agriculture and Food, Queensland Bioscience Precinct, St Lucia, QLD, 4072, Australia.ORCID 0000-0002-8224-7634
Zoltan DekanInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.ORCID 0000-0002-6841-4176
Andy SombkeDepartment of Evolutionary Biology, Integrative Zoology, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-7383-440X
Paul F AlewoodInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Bryan G FrySchool of Biological Sciences, The University of Queensland, St. Lucia, QLD, 4072, Australia.ORCID 0000-0001-6661-1283
Marc E EpsteinPlant Pest Diagnostics Branch, California Department of Food and Agriculture, Sacramento, CA 95832-1448.
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.ORCID 0000-0002-3594-9588
Glenn F KingInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia; a.walker@imb.uq.edu.au glenn.king@imb.uq.edu.au.ORCID 0000-0002-2308-2200
The University of Queensland · AUCommonwealth Scientific and Industrial Research Organisation · AUCalifornia Department of Food and Agriculture · USUniversity of Vienna · ATYork University · CA

Funding

Discovery and development of voltage-gated sodium channel inhibitorsZIABC012003 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHROEDER, INGRID · 2020 to 2022
$291k
Wellcome Trust
6 · The paper itself

Abstract

Venoms have evolved independently several times in Lepidoptera. Limacodidae is a family with worldwide distribution, many of which are venomous in the larval stage, but the composition and mode of action of their venom is unknown. Here, we use imaging technologies, transcriptomics, proteomics, and functional assays to provide a holistic picture of the venom system of a limacodid caterpillar,

Indexed as

AnimalsArthropod VenomsEvolution, MolecularInsect ProteinsLepidopteraMothsNeuropeptidesPainPeptidesProteomicsSpider VenomsTranscriptomeArthropod Venomscorazonin protein, insectInsect ProteinsNeuropeptidesPeptidesSpider VenomscecropinLepidopteraLimacodidaetoxinvenom peptide

Identifiers

PMID33893140
PMCPMC8106304
OpenAlexW3154198944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.