Evidence map›Paper›PMID 33893121›Full record

ArticleApplied and environmental microbiology2021

Transcriptomic and Metabolomic Responses to Carbon and Nitrogen Sources in Methylomicrobium album BG8.

Scott Sugden, Marina Lazic, Dominic Sauvageau, Lisa Y Stein

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Growth, physiology, and metabolism ofFrontiers in microbiology · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Transcriptional and metabolomic responses ofFrontiers in microbiology · 2023
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Scott SugdenDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Marina LazicDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Dominic SauvageauDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada.
Lisa Y SteinDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methanotrophs use methane as their sole carbon and energy source and represent an attractive platform for converting single-carbon feedstocks into value-added compounds. Optimizing these species for biotechnological applications involves choosing an optimal growth substrate based on an understanding of cellular responses to different nutrients. Although many studies of methanotrophs have examined growth rate, yield, and central carbon flux in cultures grown with different carbon and nitrogen sources, few studies have examined more global cellular responses to different media. Here, we evaluated global transcriptomic and metabolomic profiles of Methylomicrobium album BG8 when grown with methane or methanol as the carbon source and nitrate or ammonium as the nitrogen source. We identified five key physiological changes during growth on methanol:

Indexed as

Ammonium CompoundsCarbohydrate MetabolismCarbonFormaldehydeGlutathioneMetabolomeMetabolomicsMethaneMethanolMethylococcaceaeNitratesNitrogenOxidoreductasesPhospholipidsRibosomesTranscriptomeAmmonium CompoundsCarbonFormaldehydeGlutathionehydroxylamine dehydrogenaseMethaneMethanolNitratesNitrogenOxidoreductasesPhospholipidsammoniummetabolomemethanemethanolmethanotrophMethylomicrobium album BG8nitratetranscriptome

Identifiers

PMID33893121
PMCPMC8316095
OpenAlexW3154135158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.