Evidence map›Paper›PMID 33893065›Full record

ArticleTrends in cancer2021

Synovial Sarcoma Oncogenesis Revealed by Single-Cell Profiling.

Alvin Qiu, Torsten O Nielsen

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Alvin QiuFaculty of Medicine, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.
Torsten O NielsenFaculty of Medicine, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address: torsten@mail.ubc.ca.
University of British Columbia · CAVancouver Coastal Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synovial sarcoma is a soft tissue malignancy driven by the SS18-SSX fusion oncoprotein. In Nature Medicine, Jerby-Arnon et al. present a single-cell dataset for synovial sarcoma that reveals a novel 'core oncogenic program' driven by SS18-SSX, with implications for treatment strategies based on epigenetics, cell-cycle control, and immune augmentation.

Indexed as

Sarcoma, SynovialCarcinogenesisEpigenesis, GeneticHumansOncogene Proteins, FusionOncogene Proteins, Fusionepigeneticsimmune exclusionsingle-cellSS18–SSXsynovial sarcoma

Identifiers

PMID33893065
OpenAlexW3156392024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.