Evidence map›Paper›PMID 33892814›Full record

ArticleActa neuropathologica communications2021

Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction.

M Rebecca Glineburg, Yuan Zhang, Amy Krans, Elizabeth M Tank, Sami J Barmada, Peter K Todd

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. AAGGG repeat expansions triggerScience advances · 2024
    Article
  5. Article
  6. Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Moderate intrinsic phenotypic alterations inFrontiers in cellular neuroscience · 2023
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

M Rebecca Glineburg *Department of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 4005 BSRB48109-2200, USA.
Yuan Zhang *Department of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 4005 BSRB48109-2200, USA.
Amy KransDepartment of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 4005 BSRB48109-2200, USA.
Elizabeth M TankDepartment of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 4005 BSRB48109-2200, USA.
Sami J BarmadaDepartment of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 4005 BSRB48109-2200, USA.
Peter K ToddDepartment of Neurology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 4005 BSRB48109-2200, USA. Petertod@umich.edu.ORCID 0000-0003-4781-6376
University of Michigan · USCentral South University · CN

Funding

The FMR1 CGG repeat as functional element and therapeutic target in Fragile X associated disordersP50HD104463 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN · 2020 to 2024
$9.0M
Hexanucleotide repeat translation in ALS and Frontotemporal DementiaR01NS099280 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter K Todd · 2016 to 2026
$4.9M
CGG repeat associated translation in Fragile X-associated Tremor/Ataxia Syndrome-Diversity SupplementR01NS086810 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TODD, PETER K · 2014 to 2024
$4.1M
RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degenerationR01NS097542 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2016 to 2025
$3.8M
Atypical TDP43 isoforrms driving neurodegeneration in FTD/ALSR01NS113943 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2020 to 2024
$1.9M
Bypassing cellular stress pathways in frontotemporal dementia and ALSI01BX004842 · VA · VETERANS HEALTH ADMINISTRATION · PI TODD, PETER K · 2020 to 2023
–
BLRD VA I01 BX004842National Institute of Child Health and Human Development P50HD104463NICHD NIH HHS P50 HD104463NINDS NIH HHS R01 NS086810NINDS NIH HHS R01NS086810NINDS NIH HHS R01 NS097542NINDS NIH HHS R01 NS099280NINDS NIH HHS R01NS099280NINDS NIH HHS R01 NS113943NINDS NIH HHS T32NS00722237U.S. Department of Veterans Affairs BLRD BX004842
6 · The paper itself

Abstract

Transcribed nucleotide repeat expansions form detectable RNA foci in patient cells that contribute to disease pathogenesis. The most widely used method for detecting RNA foci, fluorescence in situ hybridization (FISH), is powerful but can suffer from issues related to signal above background. Here we developed a repeat-specific form of hybridization chain reaction (R-HCR) as an alternative method for detection of repeat RNA foci in two neurodegenerative disorders: C9orf72 associated ALS and frontotemporal dementia (C9 ALS/FTD) and Fragile X-associated tremor/ataxia syndrome. R-HCR to both G

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinCells, CulturedDNA Repeat ExpansionFibroblastsFrontotemporal DementiaHumansIn Situ Hybridization, FluorescenceRNA, MessengerC9orf72 ProteinC9orf72 protein, humanRNA, MessengerAmyotrophic lateral sclerosisC9orf72Fragile XFXTASG3BPRepeat-associated non-AUG (RAN) translationRNA fociRNA GelationStress granules

Identifiers

PMID33892814
PMCPMC8063431
OpenAlexW3155806112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.