Evidence map›Paper›PMID 33892809›Full record

ArticleEuropean journal of medical research2021

Risk factors for surgery-related muscle quantity and muscle quality loss and their impact on outcome.

Laura van Wijk, Stijn van Duinhoven, Mike S L Liem, Donald E Bouman, Alain R Viddeleer, Joost M Klaase

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Article in European journal of medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Serum alkaline phosphatase elevation as a preoperative sarcopenic biomarker in digestive cancer: a retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  17. Skeletal muscle dysfunction with advancing age.Clinical science (London, England : 1979) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura van WijkDepartment of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB, Groningen, the Netherlands. l.van.wijk@umcg.nl.ORCID http://orcid.org/0000-0003-2805-9488
Stijn van DuinhovenDepartment of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB, Groningen, the Netherlands.
Mike S L LiemDepartment of Surgery, Medisch Spectrum Twente, Koningsplein 1, 7512 KZ, Enschede, the Netherlands.
Donald E BoumanDepartment of Radiology, Medisch Spectrum Twente, Koningsplein 1, 7512 KZ, Enschede, the Netherlands.
Alain R ViddeleerDepartment of Radiology, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB, Groningen, the Netherlands.
Joost M KlaaseDepartment of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgery-related loss of muscle quantity negatively affects postoperative outcomes. However, changes of muscle quality have not been fully investigated. A perioperative intervention targeting identified risk factors could improve postoperative outcome. This study investigated risk factors for surgery-related loss of muscle quantity and quality and outcomes after liver resection for colorectal liver metastasis (CRLM).

methodsData of patients diagnosed with CRLM who underwent liver resection between 2006 and 2016 were analysed. Muscle quantity (psoas muscle index [PMI]), and muscle quality, (average muscle radiation attenuation [AMA] of the psoas), were measured using computed tomography. Changes in PMI and AMA of psoas after surgery were assessed.

resultsA total of 128 patients were analysed; 67 (52%) had surgery-related loss of muscle quantity and 83 (65%) muscle quality loss. Chronic obstructive pulmonary disease (COPD) (P = 0.045) and diabetes (P = 0.003) were risk factors for surgery-related loss of muscle quantity. A higher age (P = 0.002), open resection (P = 0.003) and longer operation time (P = 0.033) were associated with muscle quality loss. Overall survival was lower in patients with both muscle quantity and quality loss compared to other categories (P = 0.049). The rate of postoperative complications was significantly higher in the group with surgery-related loss of muscle quality.

conclusionsRisk factors for surgery-related muscle loss were identified. Overall survival was lowest in patients with both muscle quantity and quality loss. Complication rate was higher in patients with surgery-related loss of muscle quality.

Indexed as

AgedColorectal NeoplasmsColorectal SurgeryFemaleFollow-Up StudiesHumansLiver NeoplasmsMalePostoperative ComplicationsPrognosisPsoas MusclesRetrospective StudiesRisk FactorsSarcopeniaSurvival RateColorectal liver metastasisLiver resectionPsoas muscle indexSurgery-related muscle quality lossSurgery-related muscle quantity lossTotal psoas area

Identifiers

PMID33892809
PMCPMC8063361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.