ArticleItalian journal of pediatrics2021
Age-specific risk factors of severe pneumonia among pediatric patients hospitalized with community-acquired pneumonia.
Article in Italian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Clinical Features and Predictors of Severity in Children Hospitalized With Human Metapneumovirus: A Multicenter Italian Study.The Pediatric infectious disease journal · 2026Observational
- Clinical features and factors associated with severe illness in pediatric acute respiratory tract infections due to Escherichia coli: a retrospective tNGS-based study.World journal of microbiology & biotechnology · 2026Article
- Development and validation of an interpretable machine learning model using routine laboratory biomarkers to stratify severe pneumonia risk in young children.Journal of advanced research · 2026Article
- Predictors of Mortality in Children Admitted With Pneumonia to a Tertiary Hospital in Ghana: A Retrospective Cohort Study.Health science reports · 2026Article
- Prediction of severe pediatric community-acquired pneumonia using multimodal fusion of chest radiographs and clinical data.BMC pediatrics · 2026Article
- Independent risk factors and predictive model for high hospitalization costs in children with Mycoplasma pneumoniae pneumonia.BMC pediatrics · 2026Article
- Stratify severe risk in children with respiratory syncytial virus pneumonia-A retrospective study based on machine learning and SHAP interpretation.Frontiers in pediatrics · 2026Article
- Hospitalisation and critical care for pneumonia among children aged 5-9 years in Bangladesh: a 10-year retrospective analysis.Journal of global health · 2025Article
- Analysis of risk factors for otitis media in hospitalized children aged ≤ 12 years with bacterial pneumonia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Clinical epidemiology of community-acquired pneumonia in children before, during, and after the COVID-19 pandemic, and independent risk factors analysis for severe community-acquired pneumonia.Journal of global health · 2025Article
- Bronchoalveolar lavage cytokine profile and clinical features as risk predictors of plastic bronchitis in children with Mycoplasma pneumoniae pneumonia.Italian journal of pediatrics · 2025Article
- Construction and verification of a risk factor prediction model for neonatal severe pneumonia.Frontiers in medicine · 2025Article
- Semiquantitative chest computed tomography scoring system to estimate severity in pediatric community-acquired pneumonia.Frontiers in pediatrics · 2025Article
- Comprehensive insights into pathogen distribution, clinical features, and outcomes in pediatric severe pneumonia.Frontiers in cellular and infection microbiology · 2025Article
- Recurrent upper respiratory tract infections in early childhood: a newly defined clinical condition.Italian journal of pediatrics · 2024Observational
- Factors based on Cox regression modeling to analyze the prognostic impact of fiberoptic bronchoscopic bronchoalveolar lavage on children with severe pneumonia.American journal of translational research · 2024Article
- Increased Incidence of Rhinovirus Pneumonia in Children During the COVID-19 Pandemic in Mexico.Advances in virology · 2024Article
- The severity of pneumonia and its association with socio-demographic factors among children under five years old in Wasit governorate hospitals, Iraq.Journal of public health in Africa · 2023Article
- Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia.ERJ open research · 2023Article
- New insights in pediatrics in 2021: choices in allergy and immunology, critical care, endocrinology, gastroenterology, genetics, haematology, infectious diseases, neonatology, neurology, nutrition, palliative care, respiratory tract illnesses and telemedicine.Italian journal of pediatrics · 2022Review
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRisk factors that predispose the development of severe community-acquired pneumonia (CAP) among pediatric CAP patients of different age ranges are yet to be identified.
methodsWe retrospectively analyzed pediatric in-patients (< 6 years old) diagnosed with CAP in our hospital. We subdivided patients into four age groups (< 6 months, 6 months-1 year, 1-2 years, and 2-6 years). Their medical records, including demographic information, clinical features, laboratory findings, and chest radiographic reports, were reviewed and collected for further analysis. Univariate logistic regression analysis and stepwise regression analysis were applied to identify risk factors associated with severe CAP and ICU admission for overall patients and age-stratified subgroups.
resultsA total of 20,174 cases were initially included. Among them, 3309 (16.40%) cases were identified as severe CAP, and 2824 (14.00%) cases required ICU admission. Potential risk factors for severe CAP and ICU admission identified by univariate analysis included younger age, rural residency, premature birth, low birth weight (LBW), formula feeding, congenital heart disease (CHD), history of pneumonia or neonatal jaundice, patients with other health issues, certain symptoms (manifesting wheezing, dyspnea, cyanosis, but have no cough or fever), abnormal laboratory findings (abnormal levels of white blood cells, albumin, and C-reactive protein and RSV infection), and chest X-ray (odds ratio [OR] > 1 for all). CHD, low albumin, proteinuria, abnormal chest x-ray were independent risks factors across different age groups, whereas birth or feeding history, history of pneumonia, cyanosis or dyspnea on admission, and RSV infection were independent risk factors for only younger kids (< 1 year), and wheezing was an independent risk factor only for older children (2-5 years old).
conclusionsRisk factors predicting disease severity among children hospitalized with CAP vary with age. Risk factor stratification of pediatric CAP based on age-specific risk factors can better guide clinical practice.
trial registrationThis study has been registered in China, with the registration number being ChiCTR2000033019 .
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