Evidence map›Paper›PMID 33892745›Full record

ReviewCell communication and signaling : CCS2021

The exosome journey: from biogenesis to uptake and intracellular signalling.

Sonam Gurung, Dany Perocheau, Loukia Touramanidou, Julien Baruteau

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication and signaling : CCS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,076 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,076citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,076 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Liquid biopsy in modern medicine: advancing diagnostics from molecular insights to clinical practice.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

1,016 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sonam GurungGenetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.
Dany PerocheauGenetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.
Loukia TouramanidouGenetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.
Julien BaruteauGenetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK. j.baruteau@ucl.ac.uk.ORCID 0000-0003-0582-540X

Funding

Innovate UK 14720London Advanced Therapy / Confidence in Collaboration award 2CiC017Medical Research Council MR/T008024/1
6 · The paper itself

Abstract

The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials testing exosomes for diagnostic and therapeutic applications are generating remarkable interest from the scientific community and investors. Exosomes are small extracellular vesicles secreted by all cell types playing intercellular communication roles in health and disease by transferring cellular cargoes such as functional proteins, metabolites and nucleic acids to recipient cells. An in-depth understanding of exosome biology is therefore essential to ensure clinical development of exosome based investigational therapeutic products. Here we summarise the most up-to-date knowkedge about the complex biological journey of exosomes from biogenesis and secretion, transport and uptake to their intracellular signalling. We delineate the major pathways and molecular players that influence each step of exosome physiology, highlighting the routes of interest, which will be of benefit to exosome manipulation and engineering. We highlight the main controversies in the field of exosome research: their adequate definition, characterisation and biogenesis at plasma membrane. We also delineate the most common identified pitfalls affecting exosome research and development. Unravelling exosome physiology is key to their ultimate progression towards clinical applications. Video Abstract.

Indexed as

Signal TransductionAnimalsBiological TransportExosomesHumansIntracellular SpaceModels, BiologicalTissue DistributionEndocytosisExosomesExtracellular vesiclesIntercellular communicationLipid raftsMultivesicular bodiesRab GTPasesTargetingTetraspanins

Identifiers

PMID33892745
PMCPMC8063428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.