Evidence map›Paper›PMID 33892653›Full record

Trial reportBMC anesthesiology2021

Longitudinal assessment of preoperative dexamethasone administration on cognitive function after cardiac surgery: a 4-year follow-up of a randomized controlled trial.

Sandro Glumac, Goran Kardum, Lidija Sodic, Cristijan Bulat, Ivan Covic, Mladen Carev, Nenad Karanovic

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02767713 (The Role of Inflammatory and Stress Response in the Pathogenesis of Cognitive Dysfunction After Cardiac Surgery), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02767713 phase4unknown statusnot on this map

The Role of Inflammatory and Stress Response in the Pathogenesis of Cognitive Dysfunction After Cardiac Surgery

TypeinterventionalSponsorClinical Hospital Center, SplitRan2015 to 2016Enrolled171ConditionsPostoperative Cognitive DysfunctionArmsDexamethasone, Placebo
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sandro GlumacDepartment of Anesthesiology and Intensive Care, University Hospital of Split, Spinciceva 1, 21000, Split, Croatia. sandro.glumac@gmail.com.
Goran KardumDepartment of Psychology, Faculty of Humanities and Social Sciences, University of Split, Split, Croatia.
Lidija SodicDepartment of Neurology, University Hospital of Split, Split, Croatia.
Cristijan BulatDepartment of Cardiac Surgery, University Hospital of Split, Split, Croatia.
Ivan CovicSchool of Medicine, University of Split, Split, Croatia.
Mladen CarevDepartment of Anesthesiology and Intensive Care, University Hospital of Split, Spinciceva 1, 21000, Split, Croatia.
Nenad KaranovicDepartment of Anesthesiology and Intensive Care, University Hospital of Split, Spinciceva 1, 21000, Split, Croatia.
University of Split · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pathogenesis of postoperative cognitive decline (POCD) is still poorly understood; however, the inflammatory response to surgical procedures seems likely to be involved. In addition, our recent randomized controlled trial showed that perioperative corticosteroid treatment may ameliorate early POCD after cardiac surgery. To assess the long-term effect of dexamethasone administration on cognitive function, we conducted a 4-year follow-up.

methodsThe patients were randomized to receive a single intravenous bolus of 0.1 mg kg

resultsOf the 161 patients analyzed previously, the current follow-up included 116 patients. Compared to the 62 patients in the placebo group, the 54 patients in the dexamethasone group showed a lower incidence of POCD on the 6th day (relative risk (RR), 0.510; 95 % confidence interval (CI), 0.241 to 1.079; p = 0.067, time interval also analyzed previously) and four years (RR, 0.459; 95 % CI, 0.192 to 1.100; p = 0.068) after cardiac surgery. The change in cognitive status between the two postoperative measurements was not significant (p = 0.010) among the patients in the dexamethasone group, in contrast to patients in the placebo group (p = 0.673).

conclusionsAlthough statistical significance was not reached in the current study, the prophylactic administration of dexamethasone seems to be useful to prevent POCD development following cardiac surgery. However, further large multicenter research is needed to confirm these directions.

trial registrationClinicalTrials.gov identifier: NCT02767713 (10/05/2016).

Indexed as

Cardiac Surgical ProceduresPremedicationAgedCognitive DysfunctionDexamethasoneDouble-Blind MethodFemaleGlucocorticoidsHumansLongitudinal StudiesMaleDexamethasoneGlucocorticoidsCardiac Surgical Procedures, Postoperative Cognitive Complications, Cognitive Dysfunction, Neuropsychological Tests, Glucocorticoids, Dexamethasone

Identifiers

PMID33892653
PMCPMC8063389
OpenAlexW3156579763

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.