Evidence map›Paper›PMID 33892507›Full record

SynthesisCardiovascular research2021

Progress in aorta and peripheral cardiovascular disease research.

Lucia Mazzolai, Adriano Alatri, Alessandra Bura Rivière, Marco De Carlo, Christian Heiss, Christine Espinola-Klein, Oliver Schlager, Henrik Sillesen, Daniel Staub, José F Rodriguez-Palomares and 3 more

Erratum issuedOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cardiovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 9 countries.

Lucia MazzolaiDivision of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Adriano AlatriDivision of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Alessandra Bura RivièreDivision of Vascular Medicine, Heart, Vessels and Metabolisms Department, Toulouse University Hospital, Toulouse, France.ORCID 0000-0001-7469-2407
Marco De CarloCardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.ORCID 0000-0002-5763-9804
Christian HeissDepartment of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.ORCID 0000-0002-3212-8995
Christine Espinola-KleinSection Angiology, Department of Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany.
Oliver SchlagerDivision of Angiology, Department of Medicine II, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, Austria.
Henrik SillesenDepartment of Vascular Surgery, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3302-6288
Daniel StaubDivision of Angiology, University Hospital Basel, University of Basel, Basel, Switzerland.
José F Rodriguez-PalomaresCardiology Department, Hospital General Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), CIBER-CV, Barcelona, Spain.ORCID 0000-0002-7229-9780
Aline VerstraetenCentre of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.ORCID 0000-0003-4740-8014
Victor AboyansDepartment of Cardiology, Dupuytren-2 University Hospital, and Inserm 1094 & IRD, Limoges University, Limoges, France.
WG on aorta and peripheral vascular diseases
Azienda Ospedaliera Universitaria Pisana · ITCentro de Investigación en Red en Enfermedades Cardiovasculares · ESInserm · FRJohannes Gutenberg University Mainz · DEMedical University of Vienna · ATUniversité Fédérale de Toulouse Midi-Pyrénées · FRUniversity of Antwerp · BEUniversity of Basel · CHUniversity of Copenhagen · DKUniversity of Surrey · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although coronavirus disease 2019 seems to be the leading topic in research number of outstanding studies have been published in the field of aorta and peripheral vascular diseases likely affecting our clinical practice in the near future. This review article highlights key research on vascular diseases published in 2020. Some studies have shed light in the pathophysiology of aortic aneurysm and dissection suggesting a potential role for kinase inhibitors as new therapeutic options. A first proteogenomic study on fibromuscular dysplasia (FMD) revealed a promising novel disease gene and provided proof-of-concept for a protein/lipid-based FMD blood test. The role of NADPH oxidases in vascular physiology, and particularly endothelial cell differentiation, is highlighted with potential for cell therapy development. Imaging of vulnerable plaque has been an intense field of research. Features of plaque vulnerability on magnetic resonance imaging as an under-recognized cause of stroke are discussed. Major clinical trials on lower extremity peripheral artery disease have shown added benefit of dual antithrombotic (aspirin plus rivaroxaban) treatment.

Indexed as

Aortic DiseasesPeripheral Vascular DiseasesAnimalsBiomedical ResearchClinical Trials as TopicCOVID-19Diffusion of InnovationHumansPrognosisAntithromboticsAortaCOVIDPeripheral artery diseaseVenous thromboembolism

Identifiers

PMID33892507
PMCPMC8600478
OpenAlexW3153802115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.