Evidence map›Paper›PMID 33892314›Full record

SynthesisJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2021

Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke.

Urvish Patel, Preeti Malik, Deep Mehta, Priyanka Rajput, Mashu Shrivastava, Madiha Naveed, Eseosa Urhoghide, Mehwish Martin, Shamima Somi, Richa Jaiswal and 6 more

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Ischemic and Hemorrhagic Cerebrovascular Events Related to COVID-19 Coagulopathy and Hypoxemia.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Urvish PatelDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Preeti MalikDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: pmalik.ma@gmail.com.
Deep MehtaClinical Research Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Priyanka RajputDepartment of Family Medicine, Jackson Park Hospital and Medical Center, Chicago, IL, USA.
Mashu ShrivastavaDepartment of Internal Medicine, Kansas university medical center, Kansas City, KS, USA.
Madiha NaveedsiParadigm Diagnostic Informatics, Pine Brook, NJ, USA.
Eseosa UrhoghideDepartment of Internal Medicine, Hudson Regional Hospital, Secaucus, NJ, USA.
Mehwish MartinDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Shamima SomiDepartment of Internal Medicine, Grand Rehabilitation and Nursing Home, Great Neck, NY, USA.
Richa JaiswalDepartment of Internal Medicine, Medical University of South Carolina, Charleston, SC, USA.
Achint PatelDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Avantika IsraniDepartment of Internal Medicine, St Mary Medical Center, Langhorne, PA, USA.
Jagmeet SinghDepartment of Internal Medicine, Geisinger Commonwealth School of Medicine, Scranton, PA, USA.
Asim KichlooDepartment of Internal Medicine, Central Michigan University, College of Medicine, Saginaw, MI, USA; USA & Department of Internal Medicine, Samaritan Medical Center, Watertown, NY, USA.
Shamik ShahDepartment of Neurology, Stormont Vail Health, Topeka, KS, USA.
Abhishek LunagariyaDepartment of Neurology, University of Central Florida - HCA Consortium Neurology, Orlando, Florida, USA.
Icahn School of Medicine at Mount Sinai · USCentral Michigan University · USGeisinger Commonwealth School of Medicine · USJackson Memorial Hospital · USMedical University of South Carolina · USSt. Mary Medical Center · USStormont Vail Health · USUniversity of Central Florida · USUniversity of Kansas Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is limited literature on coronavirus disease 2019 (COVID -19) complications such as thromboembolism, cardiac complications etc. as possible trigger for stroke. Hence, we aim to evaluate the prevalence and outcomes of COVID-19 related cardiovascular complications and secondary infection and their possibility as potential triggers for the stroke.

methodsData from observational studies describing the complications [acute cardiac injury (ACI), cardiac arrhythmias (CA), disseminated intravascular coagulation (DIC), septic shock, secondary infection] and outcomes of COVID-19 hospitalized patients from December 1, 2019 to June 30, 2020, were extracted following PRISMA guidelines. Adverse outcomes defined as intensive care units, oxygen saturation less than 90%, invasive mechanical ventilation, severe disease, and in-hospital mortality. The odds ratio and 95% confidence interval were obtained, and forest plots were created using random-effects models. A short review of these complications as triggers of stroke was conducted.

results16 studies with 3480 confirmed COVID-19 patients, prevalence of ACI [38%vs5.9%], CA [26%vs5.3%], DIC [4%vs0.74%], septic shock [18%vs0.36%], and infection [30%vs12.5%] was higher among patients with poor outcomes. In meta-analysis, ACI [aOR:9.93(95%CI:3.95-25.00], CA [7.52(3.29-17.18)], DIC [7.36(1.24-43.73)], septic shock [30.12(7.56-120.10)], and infection [10.41(4.47-24.27)] had higher odds of adverse outcomes. Patients hospitalized with acute ischemic stroke and intracerebral hemorrhage, had complications like pulmonary embolism, venous thromboembolism, DIC, etc. and had poor outcomes

conclusionThe complications like acute cardiac injury, cardiac arrhythmias, DIC, septic shock, and secondary infection had poor outcomes. Patients with stroke were having history of these complications. Long term monitoring is required in such patients to prevent stroke and mitigate adverse outcomes.

Indexed as

AdultAgedArrhythmias, CardiacCOVID-19Disseminated Intravascular CoagulationFemaleHospitalizationHospital MortalityHumansIschemic StrokeMaleMiddle AgedObservational Studies as TopicPrevalencePrognosisRisk AssessmentCardiac arrhythmiaCoronary Artery DiseaseCOVID-19Deep vein thrombosisDisseminated intravascular coagulationPulmonary embolismSeptic shockStroke

Identifiers

PMID33892314
PMCPMC8026256
OpenAlexW3155533716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.